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Clinical significance of exosomes as potential biomarkers in cancer

BACKGROUND: Exosomes are microvesicles, measuring 30-100 nm in diameter. They are widely distributed in body fluids, including blood, bile, urine and saliva. Cancer-derived exosomes carry a wide variety of DNA, RNA, proteins and lipids, and may serve as novel biomarkers in cancer. AIM: To summarize...

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Autores principales: Wong, Chi-Hin, Chen, Yang-Chao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Baishideng Publishing Group Inc 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6354096/
https://www.ncbi.nlm.nih.gov/pubmed/30705894
http://dx.doi.org/10.12998/wjcc.v7.i2.171
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author Wong, Chi-Hin
Chen, Yang-Chao
author_facet Wong, Chi-Hin
Chen, Yang-Chao
author_sort Wong, Chi-Hin
collection PubMed
description BACKGROUND: Exosomes are microvesicles, measuring 30-100 nm in diameter. They are widely distributed in body fluids, including blood, bile, urine and saliva. Cancer-derived exosomes carry a wide variety of DNA, RNA, proteins and lipids, and may serve as novel biomarkers in cancer. AIM: To summarize the performance of exosomal biomarkers in cancer diagnosis and prognosis. METHODS: Relevant publications in the literature were identified by search of the “PubMed” database up to September 11, 2018. The quality of the included studies was assessed by QUADAS-2 and REMARK. For assessment of diagnostic biomarkers, 47 biomarkers and 2240 patients from 30 studies were included. RESULTS: Our results suggested that these exosomal biomarkers had excellent diagnostic ability in various types of cancer, with good sensitivity and specificity. For assessment of prognostic markers, 50 biomarkers and 4797 patients from 42 studies were included. We observed that exosomal biomarkers had prognostic values in overall survival, disease-free survival and recurrence-free survival. CONCLUSION: Exosomes can function as potential biomarkers in cancer diagnosis and prognosis.
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spelling pubmed-63540962019-01-31 Clinical significance of exosomes as potential biomarkers in cancer Wong, Chi-Hin Chen, Yang-Chao World J Clin Cases Systematic Review BACKGROUND: Exosomes are microvesicles, measuring 30-100 nm in diameter. They are widely distributed in body fluids, including blood, bile, urine and saliva. Cancer-derived exosomes carry a wide variety of DNA, RNA, proteins and lipids, and may serve as novel biomarkers in cancer. AIM: To summarize the performance of exosomal biomarkers in cancer diagnosis and prognosis. METHODS: Relevant publications in the literature were identified by search of the “PubMed” database up to September 11, 2018. The quality of the included studies was assessed by QUADAS-2 and REMARK. For assessment of diagnostic biomarkers, 47 biomarkers and 2240 patients from 30 studies were included. RESULTS: Our results suggested that these exosomal biomarkers had excellent diagnostic ability in various types of cancer, with good sensitivity and specificity. For assessment of prognostic markers, 50 biomarkers and 4797 patients from 42 studies were included. We observed that exosomal biomarkers had prognostic values in overall survival, disease-free survival and recurrence-free survival. CONCLUSION: Exosomes can function as potential biomarkers in cancer diagnosis and prognosis. Baishideng Publishing Group Inc 2019-01-26 2019-01-26 /pmc/articles/PMC6354096/ /pubmed/30705894 http://dx.doi.org/10.12998/wjcc.v7.i2.171 Text en ©The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved. http://creativecommons.org/licenses/by-nc/4.0/ This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial.
spellingShingle Systematic Review
Wong, Chi-Hin
Chen, Yang-Chao
Clinical significance of exosomes as potential biomarkers in cancer
title Clinical significance of exosomes as potential biomarkers in cancer
title_full Clinical significance of exosomes as potential biomarkers in cancer
title_fullStr Clinical significance of exosomes as potential biomarkers in cancer
title_full_unstemmed Clinical significance of exosomes as potential biomarkers in cancer
title_short Clinical significance of exosomes as potential biomarkers in cancer
title_sort clinical significance of exosomes as potential biomarkers in cancer
topic Systematic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6354096/
https://www.ncbi.nlm.nih.gov/pubmed/30705894
http://dx.doi.org/10.12998/wjcc.v7.i2.171
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