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CD5-Positive Primary Cutaneous Diffuse Large B-Cell Lymphoma-Leg Type
Most primary cutaneous B-cell lymphomas (PCBCL) are CD5 negative, and only a few cases were found to express CD5. We report the first well-documented CD5+ primary cutaneous diffuse large B-cell lymphoma-leg type (PCDLBCL-LT). A 71-year-old woman with a history of Multiple Sclerosis was admitted beca...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6354159/ https://www.ncbi.nlm.nih.gov/pubmed/30792929 http://dx.doi.org/10.1155/2019/3730915 |
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author | Papoudou-Bai, Alexandra Marinos, Leonidas Vassou, Amalia Kapsali, Eleni Kanavaros, Panagiotis |
author_facet | Papoudou-Bai, Alexandra Marinos, Leonidas Vassou, Amalia Kapsali, Eleni Kanavaros, Panagiotis |
author_sort | Papoudou-Bai, Alexandra |
collection | PubMed |
description | Most primary cutaneous B-cell lymphomas (PCBCL) are CD5 negative, and only a few cases were found to express CD5. We report the first well-documented CD5+ primary cutaneous diffuse large B-cell lymphoma-leg type (PCDLBCL-LT). A 71-year-old woman with a history of Multiple Sclerosis was admitted because of a nodule at the left thigh. Histological examination of the skin biopsy disclosed a diffuse dermal infiltration by large lymphoid cells. Immunohistochemistry revealed that these large cells were positive for CD5, CD20, CD79a, MUM1/IRF4, Bcl6, Bcl2, and cytoplasmic IgM/λ, whereas CD3, CD56, CD23, CD21, CD10, CD30, cyclin D1, CD68, lysozyme, myeloperoxidase, and CD34 were not detected. Thus, the diagnosis of a CD5+ PCDLBCL-LT was made. Despite treatment, the patient died 11 months after initial diagnosis. |
format | Online Article Text |
id | pubmed-6354159 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Hindawi |
record_format | MEDLINE/PubMed |
spelling | pubmed-63541592019-02-21 CD5-Positive Primary Cutaneous Diffuse Large B-Cell Lymphoma-Leg Type Papoudou-Bai, Alexandra Marinos, Leonidas Vassou, Amalia Kapsali, Eleni Kanavaros, Panagiotis Case Rep Dermatol Med Case Report Most primary cutaneous B-cell lymphomas (PCBCL) are CD5 negative, and only a few cases were found to express CD5. We report the first well-documented CD5+ primary cutaneous diffuse large B-cell lymphoma-leg type (PCDLBCL-LT). A 71-year-old woman with a history of Multiple Sclerosis was admitted because of a nodule at the left thigh. Histological examination of the skin biopsy disclosed a diffuse dermal infiltration by large lymphoid cells. Immunohistochemistry revealed that these large cells were positive for CD5, CD20, CD79a, MUM1/IRF4, Bcl6, Bcl2, and cytoplasmic IgM/λ, whereas CD3, CD56, CD23, CD21, CD10, CD30, cyclin D1, CD68, lysozyme, myeloperoxidase, and CD34 were not detected. Thus, the diagnosis of a CD5+ PCDLBCL-LT was made. Despite treatment, the patient died 11 months after initial diagnosis. Hindawi 2019-01-16 /pmc/articles/PMC6354159/ /pubmed/30792929 http://dx.doi.org/10.1155/2019/3730915 Text en Copyright © 2019 Alexandra Papoudou-Bai et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Case Report Papoudou-Bai, Alexandra Marinos, Leonidas Vassou, Amalia Kapsali, Eleni Kanavaros, Panagiotis CD5-Positive Primary Cutaneous Diffuse Large B-Cell Lymphoma-Leg Type |
title | CD5-Positive Primary Cutaneous Diffuse Large B-Cell Lymphoma-Leg Type |
title_full | CD5-Positive Primary Cutaneous Diffuse Large B-Cell Lymphoma-Leg Type |
title_fullStr | CD5-Positive Primary Cutaneous Diffuse Large B-Cell Lymphoma-Leg Type |
title_full_unstemmed | CD5-Positive Primary Cutaneous Diffuse Large B-Cell Lymphoma-Leg Type |
title_short | CD5-Positive Primary Cutaneous Diffuse Large B-Cell Lymphoma-Leg Type |
title_sort | cd5-positive primary cutaneous diffuse large b-cell lymphoma-leg type |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6354159/ https://www.ncbi.nlm.nih.gov/pubmed/30792929 http://dx.doi.org/10.1155/2019/3730915 |
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