Cargando…

CD5-Positive Primary Cutaneous Diffuse Large B-Cell Lymphoma-Leg Type

Most primary cutaneous B-cell lymphomas (PCBCL) are CD5 negative, and only a few cases were found to express CD5. We report the first well-documented CD5+ primary cutaneous diffuse large B-cell lymphoma-leg type (PCDLBCL-LT). A 71-year-old woman with a history of Multiple Sclerosis was admitted beca...

Descripción completa

Detalles Bibliográficos
Autores principales: Papoudou-Bai, Alexandra, Marinos, Leonidas, Vassou, Amalia, Kapsali, Eleni, Kanavaros, Panagiotis
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6354159/
https://www.ncbi.nlm.nih.gov/pubmed/30792929
http://dx.doi.org/10.1155/2019/3730915
_version_ 1783391129325010944
author Papoudou-Bai, Alexandra
Marinos, Leonidas
Vassou, Amalia
Kapsali, Eleni
Kanavaros, Panagiotis
author_facet Papoudou-Bai, Alexandra
Marinos, Leonidas
Vassou, Amalia
Kapsali, Eleni
Kanavaros, Panagiotis
author_sort Papoudou-Bai, Alexandra
collection PubMed
description Most primary cutaneous B-cell lymphomas (PCBCL) are CD5 negative, and only a few cases were found to express CD5. We report the first well-documented CD5+ primary cutaneous diffuse large B-cell lymphoma-leg type (PCDLBCL-LT). A 71-year-old woman with a history of Multiple Sclerosis was admitted because of a nodule at the left thigh. Histological examination of the skin biopsy disclosed a diffuse dermal infiltration by large lymphoid cells. Immunohistochemistry revealed that these large cells were positive for CD5, CD20, CD79a, MUM1/IRF4, Bcl6, Bcl2, and cytoplasmic IgM/λ, whereas CD3, CD56, CD23, CD21, CD10, CD30, cyclin D1, CD68, lysozyme, myeloperoxidase, and CD34 were not detected. Thus, the diagnosis of a CD5+ PCDLBCL-LT was made. Despite treatment, the patient died 11 months after initial diagnosis.
format Online
Article
Text
id pubmed-6354159
institution National Center for Biotechnology Information
language English
publishDate 2019
publisher Hindawi
record_format MEDLINE/PubMed
spelling pubmed-63541592019-02-21 CD5-Positive Primary Cutaneous Diffuse Large B-Cell Lymphoma-Leg Type Papoudou-Bai, Alexandra Marinos, Leonidas Vassou, Amalia Kapsali, Eleni Kanavaros, Panagiotis Case Rep Dermatol Med Case Report Most primary cutaneous B-cell lymphomas (PCBCL) are CD5 negative, and only a few cases were found to express CD5. We report the first well-documented CD5+ primary cutaneous diffuse large B-cell lymphoma-leg type (PCDLBCL-LT). A 71-year-old woman with a history of Multiple Sclerosis was admitted because of a nodule at the left thigh. Histological examination of the skin biopsy disclosed a diffuse dermal infiltration by large lymphoid cells. Immunohistochemistry revealed that these large cells were positive for CD5, CD20, CD79a, MUM1/IRF4, Bcl6, Bcl2, and cytoplasmic IgM/λ, whereas CD3, CD56, CD23, CD21, CD10, CD30, cyclin D1, CD68, lysozyme, myeloperoxidase, and CD34 were not detected. Thus, the diagnosis of a CD5+ PCDLBCL-LT was made. Despite treatment, the patient died 11 months after initial diagnosis. Hindawi 2019-01-16 /pmc/articles/PMC6354159/ /pubmed/30792929 http://dx.doi.org/10.1155/2019/3730915 Text en Copyright © 2019 Alexandra Papoudou-Bai et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Papoudou-Bai, Alexandra
Marinos, Leonidas
Vassou, Amalia
Kapsali, Eleni
Kanavaros, Panagiotis
CD5-Positive Primary Cutaneous Diffuse Large B-Cell Lymphoma-Leg Type
title CD5-Positive Primary Cutaneous Diffuse Large B-Cell Lymphoma-Leg Type
title_full CD5-Positive Primary Cutaneous Diffuse Large B-Cell Lymphoma-Leg Type
title_fullStr CD5-Positive Primary Cutaneous Diffuse Large B-Cell Lymphoma-Leg Type
title_full_unstemmed CD5-Positive Primary Cutaneous Diffuse Large B-Cell Lymphoma-Leg Type
title_short CD5-Positive Primary Cutaneous Diffuse Large B-Cell Lymphoma-Leg Type
title_sort cd5-positive primary cutaneous diffuse large b-cell lymphoma-leg type
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6354159/
https://www.ncbi.nlm.nih.gov/pubmed/30792929
http://dx.doi.org/10.1155/2019/3730915
work_keys_str_mv AT papoudoubaialexandra cd5positiveprimarycutaneousdiffuselargebcelllymphomalegtype
AT marinosleonidas cd5positiveprimarycutaneousdiffuselargebcelllymphomalegtype
AT vassouamalia cd5positiveprimarycutaneousdiffuselargebcelllymphomalegtype
AT kapsalieleni cd5positiveprimarycutaneousdiffuselargebcelllymphomalegtype
AT kanavarospanagiotis cd5positiveprimarycutaneousdiffuselargebcelllymphomalegtype