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Crosstalk between Fas and S1P(1) signaling via NF-kB in osteoclasts controls bone destruction in the TMJ due to rheumatoid arthritis

Rheumatoid arthritis (RA) mainly affects various joints of the body, including the temporomandibular joint (TMJ), and it involves an infiltration of autoantibodies and inflammatory leukocytes into articular tissues and the synovium. Initially, the synovial lining tissue becomes engaged with several...

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Detalles Bibliográficos
Autores principales: Hutami, Islamy Rahma, Tanaka, Eiji, Izawa, Takashi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6354287/
https://www.ncbi.nlm.nih.gov/pubmed/30733840
http://dx.doi.org/10.1016/j.jdsr.2018.09.004
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author Hutami, Islamy Rahma
Tanaka, Eiji
Izawa, Takashi
author_facet Hutami, Islamy Rahma
Tanaka, Eiji
Izawa, Takashi
author_sort Hutami, Islamy Rahma
collection PubMed
description Rheumatoid arthritis (RA) mainly affects various joints of the body, including the temporomandibular joint (TMJ), and it involves an infiltration of autoantibodies and inflammatory leukocytes into articular tissues and the synovium. Initially, the synovial lining tissue becomes engaged with several kinds of infiltrating cells, including osteoclasts, macrophages, lymphocytes, and plasma cells. Eventually, bone degradation occurs. In order to elucidate the best therapy for RA, a comprehensive study of RA pathogenesis needs to be completed. In this article, we discuss a Fas-deficient condition which develops into RA, with an emphasis on the role of sphingosine 1-phosphate (S1P)/S1P receptor 1 signaling which induces the migration of osteoclast precursor cells. We describe that Fas/S1P(1) signaling via NF-κB activation in osteoclasts is a key factor in TMJ-RA severity and we discuss a strategy for blocking nuclear translocation of the p50 NF-κB subunit as a potential therapy for attenuating osteoclastogenesis.
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spelling pubmed-63542872019-02-07 Crosstalk between Fas and S1P(1) signaling via NF-kB in osteoclasts controls bone destruction in the TMJ due to rheumatoid arthritis Hutami, Islamy Rahma Tanaka, Eiji Izawa, Takashi Jpn Dent Sci Rev Article Rheumatoid arthritis (RA) mainly affects various joints of the body, including the temporomandibular joint (TMJ), and it involves an infiltration of autoantibodies and inflammatory leukocytes into articular tissues and the synovium. Initially, the synovial lining tissue becomes engaged with several kinds of infiltrating cells, including osteoclasts, macrophages, lymphocytes, and plasma cells. Eventually, bone degradation occurs. In order to elucidate the best therapy for RA, a comprehensive study of RA pathogenesis needs to be completed. In this article, we discuss a Fas-deficient condition which develops into RA, with an emphasis on the role of sphingosine 1-phosphate (S1P)/S1P receptor 1 signaling which induces the migration of osteoclast precursor cells. We describe that Fas/S1P(1) signaling via NF-κB activation in osteoclasts is a key factor in TMJ-RA severity and we discuss a strategy for blocking nuclear translocation of the p50 NF-κB subunit as a potential therapy for attenuating osteoclastogenesis. Elsevier 2019-11 2018-10-26 /pmc/articles/PMC6354287/ /pubmed/30733840 http://dx.doi.org/10.1016/j.jdsr.2018.09.004 Text en © 2018 The Authors http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Article
Hutami, Islamy Rahma
Tanaka, Eiji
Izawa, Takashi
Crosstalk between Fas and S1P(1) signaling via NF-kB in osteoclasts controls bone destruction in the TMJ due to rheumatoid arthritis
title Crosstalk between Fas and S1P(1) signaling via NF-kB in osteoclasts controls bone destruction in the TMJ due to rheumatoid arthritis
title_full Crosstalk between Fas and S1P(1) signaling via NF-kB in osteoclasts controls bone destruction in the TMJ due to rheumatoid arthritis
title_fullStr Crosstalk between Fas and S1P(1) signaling via NF-kB in osteoclasts controls bone destruction in the TMJ due to rheumatoid arthritis
title_full_unstemmed Crosstalk between Fas and S1P(1) signaling via NF-kB in osteoclasts controls bone destruction in the TMJ due to rheumatoid arthritis
title_short Crosstalk between Fas and S1P(1) signaling via NF-kB in osteoclasts controls bone destruction in the TMJ due to rheumatoid arthritis
title_sort crosstalk between fas and s1p(1) signaling via nf-kb in osteoclasts controls bone destruction in the tmj due to rheumatoid arthritis
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6354287/
https://www.ncbi.nlm.nih.gov/pubmed/30733840
http://dx.doi.org/10.1016/j.jdsr.2018.09.004
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