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Dhcr24 activates the PI3K/Akt/HKII pathway and protects against dilated cardiomyopathy in mice

BACKGROUND: 24‐dehydrocholesterol reductase (Dhcr24) catalyzes the last step of cholesterol biosynthesis, which is required for normal development and anti‐apoptotic activities of tissues. We found that Dhcr24 expression decreased in the cTnT(R) (141W) dilated cardiomyopathy (DCM) transgenic mice. T...

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Detalles Bibliográficos
Autores principales:	Dong, Wei, Guan, Fei‐fei, Zhang, Xu, Gao, Shan, Liu, Ning, Chen, Wei, Zhang, Lian‐feng, Lu, Dan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2018
Materias:	Original Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6354314/ https://www.ncbi.nlm.nih.gov/pubmed/30891546 http://dx.doi.org/10.1002/ame2.12007

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