Installation of a cancer promoting WNT/SIX1 signaling axis by the oncofusion protein MLL-AF9

BACKGROUND: Chromosomal translocation-induced expression of the chromatin modifying oncofusion protein MLL-AF9 promotes acute myelocytic leukemia (AML). Whereas WNT/β-catenin signaling has previously been shown to support MLL-AF9-driven leukemogenesis, the mechanism underlying this relationship rema...

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Detalles Bibliográficos
Autores principales: Zhang, Li-shu, Kang, Xunlei, Lu, Jianming, Zhang, Yuannyu, Wu, Xiaofeng, Wu, Guojin, Zheng, Junke, Tuladhar, Rubina, Shi, Heping, Wang, Qiaoling, Morlock, Lorraine, Yao, Huiyu, Huang, Lily Jun-shen, Maire, Pascal, Kim, James, Williams, Noelle, Xu, Jian, Chen, Chuo, Zhang, Cheng Cheng, Lum, Lawrence
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2018
Materias:
Research paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6354558/
https://www.ncbi.nlm.nih.gov/pubmed/30528456
http://dx.doi.org/10.1016/j.ebiom.2018.11.039

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