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Interstitial pneumonia induced by cyclophosphamide: A case report and review of the literature
INTRODUCTION: Recently, interstitial lung disease significantly increases and it is difficult to treat. Cyclophosphamide(CP) is one drug administrated in interstitial lung disease, which can also cause pulmonary fibrosis and lung function lesion. This article present a case which exacerbated interst...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6354618/ https://www.ncbi.nlm.nih.gov/pubmed/30733918 http://dx.doi.org/10.1016/j.rmcr.2019.01.014 |
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author | Qian, Panpan Peng, Chun hong Ye, Xianwei |
author_facet | Qian, Panpan Peng, Chun hong Ye, Xianwei |
author_sort | Qian, Panpan |
collection | PubMed |
description | INTRODUCTION: Recently, interstitial lung disease significantly increases and it is difficult to treat. Cyclophosphamide(CP) is one drug administrated in interstitial lung disease, which can also cause pulmonary fibrosis and lung function lesion. This article present a case which exacerbated interstitial pneumonia after treatment by CP, aiming to enhance the understanding of the side effects of CP and standardize usage of the CP. CASE PRESENTATION: A patient of nephrotic syndrome administrated with CP suffered respiratory insufficiency requiring mechanical ventilation. Computed tomography (CT) imaging was compatible with interstitial pneumonia(IP). After treating with multimodal combination therapy (corticosteroids, immune globulins), the patient survived. The clinical characteristics of CP-related lung toxicity and/or pulmonary fibrosis should be paid more attention to avoid the serious outcomes. CONCLUSION: Although interstitial lung disease induced by CP is rare, with the current widespread usage of CP increases the risks of diffuse interstitial pneumonia and pulmonary fibrosis, which need to be noted in time to get early treatment. |
format | Online Article Text |
id | pubmed-6354618 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-63546182019-02-07 Interstitial pneumonia induced by cyclophosphamide: A case report and review of the literature Qian, Panpan Peng, Chun hong Ye, Xianwei Respir Med Case Rep Case Report INTRODUCTION: Recently, interstitial lung disease significantly increases and it is difficult to treat. Cyclophosphamide(CP) is one drug administrated in interstitial lung disease, which can also cause pulmonary fibrosis and lung function lesion. This article present a case which exacerbated interstitial pneumonia after treatment by CP, aiming to enhance the understanding of the side effects of CP and standardize usage of the CP. CASE PRESENTATION: A patient of nephrotic syndrome administrated with CP suffered respiratory insufficiency requiring mechanical ventilation. Computed tomography (CT) imaging was compatible with interstitial pneumonia(IP). After treating with multimodal combination therapy (corticosteroids, immune globulins), the patient survived. The clinical characteristics of CP-related lung toxicity and/or pulmonary fibrosis should be paid more attention to avoid the serious outcomes. CONCLUSION: Although interstitial lung disease induced by CP is rare, with the current widespread usage of CP increases the risks of diffuse interstitial pneumonia and pulmonary fibrosis, which need to be noted in time to get early treatment. Elsevier 2019-01-26 /pmc/articles/PMC6354618/ /pubmed/30733918 http://dx.doi.org/10.1016/j.rmcr.2019.01.014 Text en © 2019 The Authors http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Case Report Qian, Panpan Peng, Chun hong Ye, Xianwei Interstitial pneumonia induced by cyclophosphamide: A case report and review of the literature |
title | Interstitial pneumonia induced by cyclophosphamide: A case report and review of the literature |
title_full | Interstitial pneumonia induced by cyclophosphamide: A case report and review of the literature |
title_fullStr | Interstitial pneumonia induced by cyclophosphamide: A case report and review of the literature |
title_full_unstemmed | Interstitial pneumonia induced by cyclophosphamide: A case report and review of the literature |
title_short | Interstitial pneumonia induced by cyclophosphamide: A case report and review of the literature |
title_sort | interstitial pneumonia induced by cyclophosphamide: a case report and review of the literature |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6354618/ https://www.ncbi.nlm.nih.gov/pubmed/30733918 http://dx.doi.org/10.1016/j.rmcr.2019.01.014 |
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