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Circulating osteogenic precursor cells: Building bone from blood
Circulating osteogenic precursor (COP) cells constitute a recently discovered population of circulating progenitor cells with the capacity to form not only bone but other mesenchymal tissues. There is a small, but growing body of literature exploring these cells, but with a great deal of disagreemen...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6354620/ https://www.ncbi.nlm.nih.gov/pubmed/30522933 http://dx.doi.org/10.1016/j.ebiom.2018.11.051 |
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author | Feehan, Jack Nurgali, Kulmira Apostolopoulos, Vasso Al Saedi, Ahmed Duque, Gustavo |
author_facet | Feehan, Jack Nurgali, Kulmira Apostolopoulos, Vasso Al Saedi, Ahmed Duque, Gustavo |
author_sort | Feehan, Jack |
collection | PubMed |
description | Circulating osteogenic precursor (COP) cells constitute a recently discovered population of circulating progenitor cells with the capacity to form not only bone but other mesenchymal tissues. There is a small, but growing body of literature exploring these cells, but with a great deal of disagreement and contradiction within it. This review explores the origins and biological characterization of these cells, including the identification strategies used to isolate these cells from the peripheral blood. It also examines the available knowledge on the in vitro and in vivo behaviour of these cells, in the areas of plastic adherence, differentiation capacity, proliferation, and cellular homing. We also review the implications for future use of COP cells in clinical practice, particularly in the area of regenerative medicine and the treatment and assessment of musculoskeletal disease. |
format | Online Article Text |
id | pubmed-6354620 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-63546202019-02-07 Circulating osteogenic precursor cells: Building bone from blood Feehan, Jack Nurgali, Kulmira Apostolopoulos, Vasso Al Saedi, Ahmed Duque, Gustavo EBioMedicine Review Circulating osteogenic precursor (COP) cells constitute a recently discovered population of circulating progenitor cells with the capacity to form not only bone but other mesenchymal tissues. There is a small, but growing body of literature exploring these cells, but with a great deal of disagreement and contradiction within it. This review explores the origins and biological characterization of these cells, including the identification strategies used to isolate these cells from the peripheral blood. It also examines the available knowledge on the in vitro and in vivo behaviour of these cells, in the areas of plastic adherence, differentiation capacity, proliferation, and cellular homing. We also review the implications for future use of COP cells in clinical practice, particularly in the area of regenerative medicine and the treatment and assessment of musculoskeletal disease. Elsevier 2018-12-03 /pmc/articles/PMC6354620/ /pubmed/30522933 http://dx.doi.org/10.1016/j.ebiom.2018.11.051 Text en © 2018 The Authors http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Review Feehan, Jack Nurgali, Kulmira Apostolopoulos, Vasso Al Saedi, Ahmed Duque, Gustavo Circulating osteogenic precursor cells: Building bone from blood |
title | Circulating osteogenic precursor cells: Building bone from blood |
title_full | Circulating osteogenic precursor cells: Building bone from blood |
title_fullStr | Circulating osteogenic precursor cells: Building bone from blood |
title_full_unstemmed | Circulating osteogenic precursor cells: Building bone from blood |
title_short | Circulating osteogenic precursor cells: Building bone from blood |
title_sort | circulating osteogenic precursor cells: building bone from blood |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6354620/ https://www.ncbi.nlm.nih.gov/pubmed/30522933 http://dx.doi.org/10.1016/j.ebiom.2018.11.051 |
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