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Concomitant type I IFN and M-CSF signaling reprograms monocyte differentiation and drives pro-tumoral arginase production

BACKGROUND: Type I IFN-based therapies against solid malignancies have yielded only limited success. How IFN affects tumor-associated macrophage (TAM) compartment to impact the therapeutic outcomes are not well understood. METHODS: The effect of an IFN-inducer poly(I:C) on tumor-infiltrating monocyt...

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Detalles Bibliográficos
Autores principales:	Tong, Yuanyuan, Zhou, Luyang, Yang, Limin, Guo, Panpan, Cao, Yanlan, Qin, F. Xiao-Feng, Liu, Jianghuai
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2018
Materias:	Research paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6354658/ https://www.ncbi.nlm.nih.gov/pubmed/30528455 http://dx.doi.org/10.1016/j.ebiom.2018.11.062

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