HDAC inhibitor valproic acid protects heart function through Foxm1 pathway after acute myocardial infarction

BACKGROUND: Epigenetic histone acetylation is a major event controlling cell functions, such as metabolism, differentiation and repair. Here, we aim to determine whether Valproic acid (VPA), a FDA approved inhibitor of histone deacetylation for bipolar disease, could protect heart against myocardial...

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Detalles Bibliográficos
Autores principales: Tian, Shuo, Lei, Ienglam, Gao, Wenbin, Liu, Liu, Guo, Yijing, Creech, Jeffery, Herron, Todd J., Xian, Shaoxiang, Ma, Peter X., Eugene Chen, Y., Li, Yongqing, Alam, Hasan B., Wang, Zhong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2018
Materias:
Research paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6354709/
https://www.ncbi.nlm.nih.gov/pubmed/30552062
http://dx.doi.org/10.1016/j.ebiom.2018.12.003

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