Effects of rising amyloidβ levels on hippocampal synaptic transmission, microglial response and cognition in APP(Swe)/PSEN1(M146V) transgenic mice

BACKGROUND: Progression of Alzheimer's disease is thought initially to depend on rising amyloidβ and its synaptic interactions. Transgenic mice (TASTPM; APP(Swe)/PSEN1(M146V)) show altered synaptic transmission, compatible with increased physiological function of amyloidβ, before plaques are de...

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Detalles Bibliográficos
Autores principales: Medawar, Evelyn, Benway, Tiffanie A., Liu, Wenfei, Hanan, Taylor A., Haslehurst, Peter, James, Owain T., Yap, Kenrick, Muessig, Laurenz, Moroni, Fabia, Nahaboo Solim, Muzammil A., Baidildinova, Gaukhar, Wang, Rui, Richardson, Jill C., Cacucci, Francesca, Salih, Dervis A., Cummings, Damian M., Edwards, Frances A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2018
Materias:
Research paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6354711/
https://www.ncbi.nlm.nih.gov/pubmed/30555043
http://dx.doi.org/10.1016/j.ebiom.2018.12.006

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