Modeling anti-CD19 CAR T cell therapy in humanized mice with human immunity and autologous leukemia

BACKGROUND: Adoptive immunotherapy using T cells expressing chimeric antigen receptors (CARs) targeting CD19 has produced remarkable clinical outcomes. However, much of the mechanisms of action, such as the development of memory responses and sources of immune cytokines, remain elusive largely due t...

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Detalles Bibliográficos
Autores principales: Jin, Chun-Hui, Xia, Jinxing, Rafiq, Sarwish, Huang, Xin, Hu, Zheng, Zhou, Xianzheng, Brentjens, Renier J., Yang, Yong-Guang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2018
Materias:
Research paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6354733/
https://www.ncbi.nlm.nih.gov/pubmed/30579863
http://dx.doi.org/10.1016/j.ebiom.2018.12.013

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