Cargando…

Imidazopyridines as Potent KDM5 Demethylase Inhibitors Promoting Reprogramming Efficiency of Human iPSCs

Pioneering human induced pluripotent stem cell (iPSC)-based pre-clinical studies have raised safety concerns and pinpointed the need for safer and more efficient approaches to generate and maintain patient-specific iPSCs. One approach is searching for compounds that influence pluripotent stem cell r...

Descripción completa

Detalles Bibliográficos
Autores principales:	Dabiri, Yasamin, Gama-Brambila, Rodrigo A., Taškova, Katerina, Herold, Kristina, Reuter, Stefanie, Adjaye, James, Utikal, Jochen, Mrowka, Ralf, Wang, Jichang, Andrade-Navarro, Miguel A., Cheng, Xinlai
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6354736/ https://www.ncbi.nlm.nih.gov/pubmed/30685712 http://dx.doi.org/10.1016/j.isci.2019.01.012

Ejemplares similares

Depletion of Demethylase KDM6 Enhances Early Neuroectoderm Commitment of Human PSCs
por: Meng, Yajing, et al.
Publicado: (2021)

Nanog-Independent Reprogramming to iPSCs with Canonical Factors
por: Carter, Ava C., et al.
Publicado: (2014)

An Overview of Direct Somatic Reprogramming: The Ins and Outs of iPSCs
por: Menon, Siddharth, et al.
Publicado: (2016)

The Defects of Epigenetic Reprogramming in Dox-Dependent Porcine-iPSCs
por: Jiang, Aiwen, et al.
Publicado: (2022)

iPSCs-based generation of vascular cells: reprogramming approaches and applications
por: Klein, Diana
Publicado: (2017)

Reprogramming efficiency and pluripotency of mule iPSCs over its parents
por: Zhang, Jia, et al.
Publicado: (2023)

Editorial for Special Issue: iPS Cells (iPSCs) for Modelling and Treatment of Human Diseases
por: Graffmann, Nina, et al.
Publicado: (2022)

Lucky iPSCs
por: Zviran, Asaf, et al.
Publicado: (2014)

iPSCs are safe!
por: Yan, Hualong, et al.
Publicado: (2017)

A Chemical Toolbox for Labeling and Degrading Engineered Cas Proteins
por: Gama-Brambila, Rodrigo A., et al.
Publicado: (2021)

Manipulation of KLF4 Expression Generates iPSCs Paused at Successive Stages of Reprogramming
por: Nishimura, Ken, et al.
Publicado: (2014)

Reprogramming LCLs to iPSCs Results in Recovery of Donor-Specific Gene Expression Signature
por: Thomas, Samantha M., et al.
Publicado: (2015)

Combined Noncoding RNA-mRNA Regulomics Signature in Reprogramming and Pluripotency in iPSCs
por: Salloum-Asfar, Salam, et al.
Publicado: (2022)

Human transcription factors responsive to initial reprogramming predominantly undergo legitimate reprogramming during fibroblast conversion to iPSCs
por: Cevallos, Ricardo R., et al.
Publicado: (2020)

X Chromosome Dosage Influences DNA Methylation Dynamics during Reprogramming to Mouse iPSCs
por: Pasque, Vincent, et al.
Publicado: (2018)

Pkm2 can enhance pluripotency in ESCs and promote somatic cell reprogramming to iPSCs
por: Qin, Shengtang, et al.
Publicado: (2017)

The relevance of mitochondrial DNA variants fluctuation during reprogramming and neuronal differentiation of human iPSCs
por: Palombo, Flavia, et al.
Publicado: (2021)

KDM6 Demethylases and Their Roles in Human Cancers
por: Hua, Chunyan, et al.
Publicado: (2021)

Functions and Interactions of Mammalian KDM5 Demethylases
por: Pavlenko, Egor, et al.
Publicado: (2022)

Targeted Integration of Inducible Caspase-9 in Human iPSCs Allows Efficient in vitro Clearance of iPSCs and iPSC-Macrophages
por: Lipus, Alexandra, et al.
Publicado: (2020)

Mitochondria fingerprint longevity in iPSCs
por: Masotti, Andrea, et al.
Publicado: (2015)

Applications of iPSCs in Cancer Research
por: Kim, Jean J
Publicado: (2015)

Reducing genomic instability in iPSCs
por: Ruiz, Sergio, et al.
Publicado: (2015)

The Challenge of Bringing iPSCs to the Patient
por: Ortuño-Costela, María del Carmen, et al.
Publicado: (2019)

iPSCs in Modeling and Therapy of Osteoarthritis
por: Csobonyeiova, Maria, et al.
Publicado: (2021)

pVHL-mediated SMAD3 degradation suppresses TGF-β signaling
por: Zhou, Jun, et al.
Publicado: (2021)

Protocol to Reprogram Human Menstrual Blood-Derived Stromal Cells to Generate AOX15-iPSCs
por: Sanzhez-Mata, Alicia, et al.
Publicado: (2020)

KDM6A/B Demethylases in Gut Homeostasis
por: Soshnikova, Natalia
Publicado: (2023)

iPSCs: From Bench to Clinical Bed
por: Li, Yujing, et al.
Publicado: (2016)

Differentiation of human iPSCs into functional podocytes
por: Rauch, Caroline, et al.
Publicado: (2018)

Targeted inhibition of KDM6 histone demethylases eradicates tumor-initiating cells via enhancer reprogramming in colorectal cancer
por: Zhang, Junbao, et al.
Publicado: (2020)

Footprint-free human fetal foreskin derived iPSCs: A tool for modeling hepatogenesis associated gene regulatory networks
por: Matz, Peggy, et al.
Publicado: (2017)

Generation of iPSCs as a Pooled Culture Using Magnetic Activated Cell Sorting of Newly Reprogrammed Cells
por: Yang, Wenli, et al.
Publicado: (2015)

In vivo reprogramming reactive glia into iPSCs to produce new neurons in the cortex following traumatic brain injury
por: Gao, Xiang, et al.
Publicado: (2016)

A critical role for p38MAPK signalling pathway during reprogramming of human fibroblasts to iPSCs
por: Neganova, Irina, et al.
Publicado: (2017)

An RNAi Screen Reveals an Essential Role for HIPK4 in Human Skin Epithelial Differentiation from iPSCs
por: Larribère, Lionel, et al.
Publicado: (2017)

The Histone Demethylase KDM5 Is Essential for Larval Growth in Drosophila
por: Drelon, Coralie, et al.
Publicado: (2018)

The nuclear bodies formed by histone demethylase KDM7A
por: Ming, Hui, et al.
Publicado: (2020)

MiR-25 Regulates Wwp2 and Fbxw7 and Promotes Reprogramming of Mouse Fibroblast Cells to iPSCs
por: Lu, Dong, et al.
Publicado: (2012)

High-Level Precise Knockin of iPSCs by Simultaneous Reprogramming and Genome Editing of Human Peripheral Blood Mononuclear Cells
por: Wen, Wei, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_bnn9nhnp5v4891fbpvmdisls2t