A Myristoyl-Binding Site in the SH3 Domain Modulates c-Src Membrane Anchoring

The c-Src oncogene is anchored to the cytoplasmic membrane through its N-terminal myristoylated SH4 domain. This domain is part of an intramolecular fuzzy complex with the SH3 and Unique domains. Here we show that the N-terminal myristoyl group binds to the SH3 domain in the proximity of the RT loop...

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Detalles Bibliográficos
Autores principales: Le Roux, Anabel-Lise, Mohammad, Irrem-Laareb, Mateos, Borja, Arbesú, Miguel, Gairí, Margarida, Khan, Farman Ali, Teixeira, João M.C., Pons, Miquel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6354742/
https://www.ncbi.nlm.nih.gov/pubmed/30690395
http://dx.doi.org/10.1016/j.isci.2019.01.010

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