Cargando…
Site-selective protein conjugation at histidine
Site-selective conjugation generally requires both (i) molecular engineering of the protein of interest to introduce a conjugation site at a defined location and (ii) a site-specific conjugation technology. Three N-terminal interferon α2-a (IFN) variants with truncated histidine tags were prepared a...
Autores principales: | Peciak, Karolina, Laurine, Emmanuelle, Tommasi, Rita, Choi, Ji-won, Brocchini, Steve |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Royal Society of Chemistry
2018
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6354831/ https://www.ncbi.nlm.nih.gov/pubmed/30809337 http://dx.doi.org/10.1039/c8sc03355b |
Ejemplares similares
-
Histidine-conjugated DNA as a biomolecular depot for metal ions
por: Park, Soyoung, et al.
Publicado: (2020) -
Linchpins empower promiscuous electrophiles to enable site-selective modification of histidine and aspartic acid in proteins
por: Rawale, Dattatraya Gautam, et al.
Publicado: (2021) -
An overview of chemo- and site-selectivity aspects in the chemical conjugation of proteins
por: Sornay, Charlotte, et al.
Publicado: (2022) -
Construction of homogeneous antibody–drug conjugates using site-selective protein chemistry
por: Akkapeddi, Padma, et al.
Publicado: (2016) -
Site-selective lysine conjugation methods and applications towards antibody–drug conjugates
por: Haque, Muhammed, et al.
Publicado: (2021)