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Effects of gender, age and treatment duration on lipid profile and renal function indices in diabetic patients attending a teaching hospital in South-Western Nigeria

BACKGROUND: Type 2 Diabetes Mellitus (T2DM) is associated with diabetic nephropathy and hyperlipidemia. Gender, age, medication adherence, lifestyle, culture and socioeconomic status could be sources of diversity in T2DM leading to differences in predisposition, development and clinical presentation...

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Autores principales: Aderibigbe, Mary Alaba, Obafemi, Tajudeen Olabisi, Olaleye, Mary Tolulope, Akinmoladun, Afolabi Clement
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Makerere Medical School 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6354870/
https://www.ncbi.nlm.nih.gov/pubmed/30766553
http://dx.doi.org/10.4314/ahs.v18i4.8
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author Aderibigbe, Mary Alaba
Obafemi, Tajudeen Olabisi
Olaleye, Mary Tolulope
Akinmoladun, Afolabi Clement
author_facet Aderibigbe, Mary Alaba
Obafemi, Tajudeen Olabisi
Olaleye, Mary Tolulope
Akinmoladun, Afolabi Clement
author_sort Aderibigbe, Mary Alaba
collection PubMed
description BACKGROUND: Type 2 Diabetes Mellitus (T2DM) is associated with diabetic nephropathy and hyperlipidemia. Gender, age, medication adherence, lifestyle, culture and socioeconomic status could be sources of diversity in T2DM leading to differences in predisposition, development and clinical presentation. OBJECTIVES: Therefore, this study aimed to investigate the influence of gender, age and treatment duration on kidney and lipid-related biochemical indices of T2DM patients attending Ekiti State University Teaching Hospital, Ado-Ekiti, Nigeria (EKSUTH). METHODS: Blood from diabetic patients and healthy subjects was analysed for fasting blood glucose (FBG), renal function parameters and lipid profile. Influence of age, gender and treatment duration on indices was assessed using standard baseline values. RESULTS: Dyslipidemia was pronounced among female diabetics while the incidence of diabetes was found to be higher in middle-age. The percentage of diabetics with high levels of FPG, urea, creatinine, cholesterol, triglyceride and low density lipoprotein-cholesterol after 9–10 years of treatment were lower compared with the percentage after 5–6 years of treatment. CONCLUSION: Gender, age and treatment duration influenced clinical course of T2DM among patients presenting at EKSUTH but long term treatment appeared to improve T2DM among patients.
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spelling pubmed-63548702019-02-14 Effects of gender, age and treatment duration on lipid profile and renal function indices in diabetic patients attending a teaching hospital in South-Western Nigeria Aderibigbe, Mary Alaba Obafemi, Tajudeen Olabisi Olaleye, Mary Tolulope Akinmoladun, Afolabi Clement Afr Health Sci Articles BACKGROUND: Type 2 Diabetes Mellitus (T2DM) is associated with diabetic nephropathy and hyperlipidemia. Gender, age, medication adherence, lifestyle, culture and socioeconomic status could be sources of diversity in T2DM leading to differences in predisposition, development and clinical presentation. OBJECTIVES: Therefore, this study aimed to investigate the influence of gender, age and treatment duration on kidney and lipid-related biochemical indices of T2DM patients attending Ekiti State University Teaching Hospital, Ado-Ekiti, Nigeria (EKSUTH). METHODS: Blood from diabetic patients and healthy subjects was analysed for fasting blood glucose (FBG), renal function parameters and lipid profile. Influence of age, gender and treatment duration on indices was assessed using standard baseline values. RESULTS: Dyslipidemia was pronounced among female diabetics while the incidence of diabetes was found to be higher in middle-age. The percentage of diabetics with high levels of FPG, urea, creatinine, cholesterol, triglyceride and low density lipoprotein-cholesterol after 9–10 years of treatment were lower compared with the percentage after 5–6 years of treatment. CONCLUSION: Gender, age and treatment duration influenced clinical course of T2DM among patients presenting at EKSUTH but long term treatment appeared to improve T2DM among patients. Makerere Medical School 2018-12 /pmc/articles/PMC6354870/ /pubmed/30766553 http://dx.doi.org/10.4314/ahs.v18i4.8 Text en © 2018 Aderibigbe et al. Licensee African Health Sciences. This is an Open Access article distributed under the terms of the Creative commons Attribution License (https://creativecommons.org/licenses/BY/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Articles
Aderibigbe, Mary Alaba
Obafemi, Tajudeen Olabisi
Olaleye, Mary Tolulope
Akinmoladun, Afolabi Clement
Effects of gender, age and treatment duration on lipid profile and renal function indices in diabetic patients attending a teaching hospital in South-Western Nigeria
title Effects of gender, age and treatment duration on lipid profile and renal function indices in diabetic patients attending a teaching hospital in South-Western Nigeria
title_full Effects of gender, age and treatment duration on lipid profile and renal function indices in diabetic patients attending a teaching hospital in South-Western Nigeria
title_fullStr Effects of gender, age and treatment duration on lipid profile and renal function indices in diabetic patients attending a teaching hospital in South-Western Nigeria
title_full_unstemmed Effects of gender, age and treatment duration on lipid profile and renal function indices in diabetic patients attending a teaching hospital in South-Western Nigeria
title_short Effects of gender, age and treatment duration on lipid profile and renal function indices in diabetic patients attending a teaching hospital in South-Western Nigeria
title_sort effects of gender, age and treatment duration on lipid profile and renal function indices in diabetic patients attending a teaching hospital in south-western nigeria
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6354870/
https://www.ncbi.nlm.nih.gov/pubmed/30766553
http://dx.doi.org/10.4314/ahs.v18i4.8
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