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Dose related effects of oral clonidine pre-medication on bupivacaine spinal anaesthesia

INTRODUCTION: The duration of action of sub-arachnoid block is short, and one of the ways to overcome this is the use of oral clonidine. METHODS: 108 patients of ASA I and II, aged 18 to 65 years undergoing lower abdominal surgeries under spinal anaesthesia were randomized into three groups.. Contro...

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Detalles Bibliográficos
Autores principales: Adegboye, MB, Kolawole, IK, Bolaji, BO
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Makerere Medical School 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6354890/
https://www.ncbi.nlm.nih.gov/pubmed/30766594
http://dx.doi.org/10.4314/ahs.v18i4.49
Descripción
Sumario:INTRODUCTION: The duration of action of sub-arachnoid block is short, and one of the ways to overcome this is the use of oral clonidine. METHODS: 108 patients of ASA I and II, aged 18 to 65 years undergoing lower abdominal surgeries under spinal anaesthesia were randomized into three groups.. Control group A (n=36) no oral clonidine pre-medication, Group B (n=36) and group C (n=36) received 100 µg and 200 µg of oral clonidine pre-medication respectively, 1hr before spinal anaesthesia. Haemodynamic parameters were recorded. Sensory block, degree of motor blockage, and sedation were assessed. RESULTS: Clonidine prolonged the mean duration of motor block by 189.98±26.93 min (100µg) and 191.89±28.13 min (200µg) compared to 117.92±25.13 min in the control group p<0.05. The mean duration of analgesia was 188.19±35 min (100µg) and194±24.58 min (200µg) in the clonidine groups compared to 115.89±26.66 min in control group p<0.05. All the patients were awake in the control group while 71.43% and 100% were drowsy in groups B and C respectively. CONCLUSION: Oral clonidine produces better clinical effects on the onset and duration of Bupivacaine spinal anaesthesia.