Cargando…

Cytomegalovirus infection among Human Immunodeficiency Virus (HIV) infected individuals on highly active anti-retroviral therapy in North-Central Nigeria

BACKGROUND: Cytomegalovirus (CMV) infection is common among HIV-infected individuals. Its contribution to morbidity and mortality became more apparent following introduction of highly active anti-retroviral therapy (HAART) which improved survival among HIV-infected individuals. OBJECTIVES: This stud...

Descripción completa

Detalles Bibliográficos
Autores principales: Udeze, Augustine, Odebisi-Omokanye, Mutiat, Ajileye, Toluwani
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Makerere Medical School 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6354892/
https://www.ncbi.nlm.nih.gov/pubmed/30766572
http://dx.doi.org/10.4314/ahs.v18i4.27
_version_ 1783391263555321856
author Udeze, Augustine
Odebisi-Omokanye, Mutiat
Ajileye, Toluwani
author_facet Udeze, Augustine
Odebisi-Omokanye, Mutiat
Ajileye, Toluwani
author_sort Udeze, Augustine
collection PubMed
description BACKGROUND: Cytomegalovirus (CMV) infection is common among HIV-infected individuals. Its contribution to morbidity and mortality became more apparent following introduction of highly active anti-retroviral therapy (HAART) which improved survival among HIV-infected individuals. OBJECTIVES: This study aimed at determining the prevalence of both active and latent CMV infections among HIV-infected individuals on HAART in Ilorin, Nigeria. METHODS: A total of 360 consented HIV-1 patients were recruited for the study. About 5ml of blood and socio-demographic data were collected from each patient. Plasma from the blood was tested for anti-CMV IgM and IgG presence using ELISA. RESULTS: Of the 360 participants tested, 42 (11.7%) and 265 (73.6%) were respectively anti-CMV IgM and IgG antibodies positive representing active and latent infection rates respectively. Gender and age were the correlates of IgM seropositivity while age, occupation and marital status correlated with IgG seropositivity. Occupation, marital status, use of HAART and CD4(+) count were not statistically associated with IgM level while gender, use of HAART and CD4+ count did not correlate with IgG level. CONCLUSIONS: This study has demonstrated high level of latent and active CMV infection among HAART recipients in Ilorin and highlighted the need for incorporation of anti-herpes drugs in the treatment regimen.
format Online
Article
Text
id pubmed-6354892
institution National Center for Biotechnology Information
language English
publishDate 2018
publisher Makerere Medical School
record_format MEDLINE/PubMed
spelling pubmed-63548922019-02-14 Cytomegalovirus infection among Human Immunodeficiency Virus (HIV) infected individuals on highly active anti-retroviral therapy in North-Central Nigeria Udeze, Augustine Odebisi-Omokanye, Mutiat Ajileye, Toluwani Afr Health Sci Articles BACKGROUND: Cytomegalovirus (CMV) infection is common among HIV-infected individuals. Its contribution to morbidity and mortality became more apparent following introduction of highly active anti-retroviral therapy (HAART) which improved survival among HIV-infected individuals. OBJECTIVES: This study aimed at determining the prevalence of both active and latent CMV infections among HIV-infected individuals on HAART in Ilorin, Nigeria. METHODS: A total of 360 consented HIV-1 patients were recruited for the study. About 5ml of blood and socio-demographic data were collected from each patient. Plasma from the blood was tested for anti-CMV IgM and IgG presence using ELISA. RESULTS: Of the 360 participants tested, 42 (11.7%) and 265 (73.6%) were respectively anti-CMV IgM and IgG antibodies positive representing active and latent infection rates respectively. Gender and age were the correlates of IgM seropositivity while age, occupation and marital status correlated with IgG seropositivity. Occupation, marital status, use of HAART and CD4(+) count were not statistically associated with IgM level while gender, use of HAART and CD4+ count did not correlate with IgG level. CONCLUSIONS: This study has demonstrated high level of latent and active CMV infection among HAART recipients in Ilorin and highlighted the need for incorporation of anti-herpes drugs in the treatment regimen. Makerere Medical School 2018-12 /pmc/articles/PMC6354892/ /pubmed/30766572 http://dx.doi.org/10.4314/ahs.v18i4.27 Text en © 2018 Udeze et al. Licensee African Health Sciences. This is an Open Access article distributed under the terms of the Creative commons Attribution License (https://creativecommons.org/licenses/BY/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Articles
Udeze, Augustine
Odebisi-Omokanye, Mutiat
Ajileye, Toluwani
Cytomegalovirus infection among Human Immunodeficiency Virus (HIV) infected individuals on highly active anti-retroviral therapy in North-Central Nigeria
title Cytomegalovirus infection among Human Immunodeficiency Virus (HIV) infected individuals on highly active anti-retroviral therapy in North-Central Nigeria
title_full Cytomegalovirus infection among Human Immunodeficiency Virus (HIV) infected individuals on highly active anti-retroviral therapy in North-Central Nigeria
title_fullStr Cytomegalovirus infection among Human Immunodeficiency Virus (HIV) infected individuals on highly active anti-retroviral therapy in North-Central Nigeria
title_full_unstemmed Cytomegalovirus infection among Human Immunodeficiency Virus (HIV) infected individuals on highly active anti-retroviral therapy in North-Central Nigeria
title_short Cytomegalovirus infection among Human Immunodeficiency Virus (HIV) infected individuals on highly active anti-retroviral therapy in North-Central Nigeria
title_sort cytomegalovirus infection among human immunodeficiency virus (hiv) infected individuals on highly active anti-retroviral therapy in north-central nigeria
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6354892/
https://www.ncbi.nlm.nih.gov/pubmed/30766572
http://dx.doi.org/10.4314/ahs.v18i4.27
work_keys_str_mv AT udezeaugustine cytomegalovirusinfectionamonghumanimmunodeficiencyvirushivinfectedindividualsonhighlyactiveantiretroviraltherapyinnorthcentralnigeria
AT odebisiomokanyemutiat cytomegalovirusinfectionamonghumanimmunodeficiencyvirushivinfectedindividualsonhighlyactiveantiretroviraltherapyinnorthcentralnigeria
AT ajileyetoluwani cytomegalovirusinfectionamonghumanimmunodeficiencyvirushivinfectedindividualsonhighlyactiveantiretroviraltherapyinnorthcentralnigeria