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Individual response to mTOR inhibition in delaying replicative senescence of mesenchymal stromal cells

BACKGROUND AIMS: Delaying replicative senescence and extending lifespan of human mesenchymal stromal cells (MSCs) may enhance their potential for tissue engineering and cell based therapies. Accumulating evidence suggests that inhibitors of the mTOR signaling pathway, such as rapamycin, constitute p...

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Detalles Bibliográficos
Autores principales:	Antonioli, Eliane, Torres, Natália, Ferretti, Mario, Piccinato, Carla de Azevedo, Sertie, Andrea Laurato
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2019
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6354956/ https://www.ncbi.nlm.nih.gov/pubmed/30703123 http://dx.doi.org/10.1371/journal.pone.0204784

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