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The Inflammatory Effects of Breast Implant Particulate Shedding: Comparison With Orthopedic Implants

Currently, there is a dearth of information regarding the degree of particle shedding from breast implants (BIs) and what are the general biological consequences of BI debris. Thus, it is unclear to what degree BI debris compromises the long-term biological performance of BIs. For orthopedic implant...

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Detalles Bibliográficos
Autores principales: Hallab, Nadim James, Samelko, Lauryn, Hammond, Dennis
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6355107/
https://www.ncbi.nlm.nih.gov/pubmed/30715176
http://dx.doi.org/10.1093/asj/sjy335
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author Hallab, Nadim James
Samelko, Lauryn
Hammond, Dennis
author_facet Hallab, Nadim James
Samelko, Lauryn
Hammond, Dennis
author_sort Hallab, Nadim James
collection PubMed
description Currently, there is a dearth of information regarding the degree of particle shedding from breast implants (BIs) and what are the general biological consequences of BI debris. Thus, it is unclear to what degree BI debris compromises the long-term biological performance of BIs. For orthopedic implants, it is well established that the severity of biological reactivity to implant debris governs long-term clinical performance. Orthopedic implant particulate debris is generally in the range of 0.01 to 100 μm in diameter. Implant debris-induced bioreactivity/inflammation is mostly a peri-implant phenomenon caused by local innate immune cells (eg, macrophages) that produce proinflammatory cytokines such as tumor necrosis factor-α, interleukin-1β, interleukin-6, and prostaglandin 2 (PGE2). In orthopedics, there have been few systemic concerns associated with polymeric implant debris (like silicone) other than documented dissemination to remote organs (eg, liver, spleen, etc.) with no known associated pathogenicity. This is not true of metal implant debris where normal (well-functioning) implants can induce systemic reactions such as delayed type hypersensitivity. Diagnostic analysis of orthopedic tissues has focused on innate (macrophage mediated) and adaptive (lymphocyte-mediated hypersensitivity) immune responses. Orthopedic implant debris-associated lymphocyte cancers have not been reported in over 40 years of orthopedic literature. Adaptive immune responses such as hypersensitivity reactions to orthopedic implant debris have been dominated by certain implant types that produce specific kinds of debris (eg, metal-on-metal total joint prostheses). Orthopedic hypersensitivity responses and atypical BI bioreactivity such as BI-associated anaplastic large cell lymphoma share crossover markers for diagnosis. Differentiating normal innate immune reactivity to particles from anaplastic large cell lymphoma reactions from delayed type hypersensitivity reactions to BI-associated implant debris remains unclear but vital to patients and surgeons.
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spelling pubmed-63551072019-02-08 The Inflammatory Effects of Breast Implant Particulate Shedding: Comparison With Orthopedic Implants Hallab, Nadim James Samelko, Lauryn Hammond, Dennis Aesthet Surg J Supplement Articles Currently, there is a dearth of information regarding the degree of particle shedding from breast implants (BIs) and what are the general biological consequences of BI debris. Thus, it is unclear to what degree BI debris compromises the long-term biological performance of BIs. For orthopedic implants, it is well established that the severity of biological reactivity to implant debris governs long-term clinical performance. Orthopedic implant particulate debris is generally in the range of 0.01 to 100 μm in diameter. Implant debris-induced bioreactivity/inflammation is mostly a peri-implant phenomenon caused by local innate immune cells (eg, macrophages) that produce proinflammatory cytokines such as tumor necrosis factor-α, interleukin-1β, interleukin-6, and prostaglandin 2 (PGE2). In orthopedics, there have been few systemic concerns associated with polymeric implant debris (like silicone) other than documented dissemination to remote organs (eg, liver, spleen, etc.) with no known associated pathogenicity. This is not true of metal implant debris where normal (well-functioning) implants can induce systemic reactions such as delayed type hypersensitivity. Diagnostic analysis of orthopedic tissues has focused on innate (macrophage mediated) and adaptive (lymphocyte-mediated hypersensitivity) immune responses. Orthopedic implant debris-associated lymphocyte cancers have not been reported in over 40 years of orthopedic literature. Adaptive immune responses such as hypersensitivity reactions to orthopedic implant debris have been dominated by certain implant types that produce specific kinds of debris (eg, metal-on-metal total joint prostheses). Orthopedic hypersensitivity responses and atypical BI bioreactivity such as BI-associated anaplastic large cell lymphoma share crossover markers for diagnosis. Differentiating normal innate immune reactivity to particles from anaplastic large cell lymphoma reactions from delayed type hypersensitivity reactions to BI-associated implant debris remains unclear but vital to patients and surgeons. Oxford University Press 2019-01 2019-01-31 /pmc/articles/PMC6355107/ /pubmed/30715176 http://dx.doi.org/10.1093/asj/sjy335 Text en © 2019 The American Society for Aesthetic Plastic Surgery, Inc. http://creativecommons.org/licenses/by-nc/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com
spellingShingle Supplement Articles
Hallab, Nadim James
Samelko, Lauryn
Hammond, Dennis
The Inflammatory Effects of Breast Implant Particulate Shedding: Comparison With Orthopedic Implants
title The Inflammatory Effects of Breast Implant Particulate Shedding: Comparison With Orthopedic Implants
title_full The Inflammatory Effects of Breast Implant Particulate Shedding: Comparison With Orthopedic Implants
title_fullStr The Inflammatory Effects of Breast Implant Particulate Shedding: Comparison With Orthopedic Implants
title_full_unstemmed The Inflammatory Effects of Breast Implant Particulate Shedding: Comparison With Orthopedic Implants
title_short The Inflammatory Effects of Breast Implant Particulate Shedding: Comparison With Orthopedic Implants
title_sort inflammatory effects of breast implant particulate shedding: comparison with orthopedic implants
topic Supplement Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6355107/
https://www.ncbi.nlm.nih.gov/pubmed/30715176
http://dx.doi.org/10.1093/asj/sjy335
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