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Omega-3 and -6 fatty acid plasma levels are not associated with liver cirrhosis-associated systemic inflammation

BACKGROUND: Liver cirrhosis is associated with profound immunodysfunction, i.e. a parallel presence of chronic systemic inflammation and immunosuppression, which can result in acute-on-chronic liver failure (ACLF). Omega-3 fatty acids are precursors of pro-resolving mediators and support the resolut...

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Autores principales: Schwarzkopf, Katharina Maria, Queck, Alexander, Thomas, Dominique, Angioni, Carlo, Cai, Chengcong, Freygang, Ylva, Rüschenbaum, Sabrina, Geisslinger, Gerd, Zeuzem, Stefan, Welsch, Christoph, Lange, Christian Markus
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6355116/
https://www.ncbi.nlm.nih.gov/pubmed/30703151
http://dx.doi.org/10.1371/journal.pone.0211537
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author Schwarzkopf, Katharina Maria
Queck, Alexander
Thomas, Dominique
Angioni, Carlo
Cai, Chengcong
Freygang, Ylva
Rüschenbaum, Sabrina
Geisslinger, Gerd
Zeuzem, Stefan
Welsch, Christoph
Lange, Christian Markus
author_facet Schwarzkopf, Katharina Maria
Queck, Alexander
Thomas, Dominique
Angioni, Carlo
Cai, Chengcong
Freygang, Ylva
Rüschenbaum, Sabrina
Geisslinger, Gerd
Zeuzem, Stefan
Welsch, Christoph
Lange, Christian Markus
author_sort Schwarzkopf, Katharina Maria
collection PubMed
description BACKGROUND: Liver cirrhosis is associated with profound immunodysfunction, i.e. a parallel presence of chronic systemic inflammation and immunosuppression, which can result in acute-on-chronic liver failure (ACLF). Omega-3 fatty acids are precursors of pro-resolving mediators and support the resolution of inflammation. OBJECTIVE: The aim of this study was to determine plasma levels of omega-3 fatty acids in patients with liver cirrhosis and ACLF. METHODS: Patients with liver cirrhosis with and without ACLF were enrolled in a prospective cohort study and analyzed post-hoc for the present sub-study. Clinical data and biomaterials were collected at baseline and at day 7, 28 and after 3 months of follow-up. Plasma concentrations of arachidonic acid (ARA) and docosahexaenoic acid (DHA), which represent key omega-6 and -3 fatty acids, respectively, were quantified and associated with markers of systemic inflammation and severity of liver cirrhosis. RESULTS: A total of 117 patients were included in the present analyses. Of those, 26 (22.2%), 51 (43.6%) and 40 (34.2%) patients had compensated or decompensated liver cirrhosis, and ACLF. Plasma levels of ARA and DHA were similar in patients with compensated cirrhosis, decompensated cirrhosis, and ACLF. Furthermore, no significant association between plasma ARA or DHA and C-reactive protein or peripheral blood leukocytes were observed (P>0.05). CONCLUSION: In our study plasma levels of key omega-3 and omega-6 fatty acid are neither associated with the severity of liver cirrhosis nor with liver-cirrhosis-associated systemic inflammation.
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spelling pubmed-63551162019-02-15 Omega-3 and -6 fatty acid plasma levels are not associated with liver cirrhosis-associated systemic inflammation Schwarzkopf, Katharina Maria Queck, Alexander Thomas, Dominique Angioni, Carlo Cai, Chengcong Freygang, Ylva Rüschenbaum, Sabrina Geisslinger, Gerd Zeuzem, Stefan Welsch, Christoph Lange, Christian Markus PLoS One Research Article BACKGROUND: Liver cirrhosis is associated with profound immunodysfunction, i.e. a parallel presence of chronic systemic inflammation and immunosuppression, which can result in acute-on-chronic liver failure (ACLF). Omega-3 fatty acids are precursors of pro-resolving mediators and support the resolution of inflammation. OBJECTIVE: The aim of this study was to determine plasma levels of omega-3 fatty acids in patients with liver cirrhosis and ACLF. METHODS: Patients with liver cirrhosis with and without ACLF were enrolled in a prospective cohort study and analyzed post-hoc for the present sub-study. Clinical data and biomaterials were collected at baseline and at day 7, 28 and after 3 months of follow-up. Plasma concentrations of arachidonic acid (ARA) and docosahexaenoic acid (DHA), which represent key omega-6 and -3 fatty acids, respectively, were quantified and associated with markers of systemic inflammation and severity of liver cirrhosis. RESULTS: A total of 117 patients were included in the present analyses. Of those, 26 (22.2%), 51 (43.6%) and 40 (34.2%) patients had compensated or decompensated liver cirrhosis, and ACLF. Plasma levels of ARA and DHA were similar in patients with compensated cirrhosis, decompensated cirrhosis, and ACLF. Furthermore, no significant association between plasma ARA or DHA and C-reactive protein or peripheral blood leukocytes were observed (P>0.05). CONCLUSION: In our study plasma levels of key omega-3 and omega-6 fatty acid are neither associated with the severity of liver cirrhosis nor with liver-cirrhosis-associated systemic inflammation. Public Library of Science 2019-01-31 /pmc/articles/PMC6355116/ /pubmed/30703151 http://dx.doi.org/10.1371/journal.pone.0211537 Text en © 2019 Schwarzkopf et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Schwarzkopf, Katharina Maria
Queck, Alexander
Thomas, Dominique
Angioni, Carlo
Cai, Chengcong
Freygang, Ylva
Rüschenbaum, Sabrina
Geisslinger, Gerd
Zeuzem, Stefan
Welsch, Christoph
Lange, Christian Markus
Omega-3 and -6 fatty acid plasma levels are not associated with liver cirrhosis-associated systemic inflammation
title Omega-3 and -6 fatty acid plasma levels are not associated with liver cirrhosis-associated systemic inflammation
title_full Omega-3 and -6 fatty acid plasma levels are not associated with liver cirrhosis-associated systemic inflammation
title_fullStr Omega-3 and -6 fatty acid plasma levels are not associated with liver cirrhosis-associated systemic inflammation
title_full_unstemmed Omega-3 and -6 fatty acid plasma levels are not associated with liver cirrhosis-associated systemic inflammation
title_short Omega-3 and -6 fatty acid plasma levels are not associated with liver cirrhosis-associated systemic inflammation
title_sort omega-3 and -6 fatty acid plasma levels are not associated with liver cirrhosis-associated systemic inflammation
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6355116/
https://www.ncbi.nlm.nih.gov/pubmed/30703151
http://dx.doi.org/10.1371/journal.pone.0211537
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