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Omega-3 and -6 fatty acid plasma levels are not associated with liver cirrhosis-associated systemic inflammation
BACKGROUND: Liver cirrhosis is associated with profound immunodysfunction, i.e. a parallel presence of chronic systemic inflammation and immunosuppression, which can result in acute-on-chronic liver failure (ACLF). Omega-3 fatty acids are precursors of pro-resolving mediators and support the resolut...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6355116/ https://www.ncbi.nlm.nih.gov/pubmed/30703151 http://dx.doi.org/10.1371/journal.pone.0211537 |
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author | Schwarzkopf, Katharina Maria Queck, Alexander Thomas, Dominique Angioni, Carlo Cai, Chengcong Freygang, Ylva Rüschenbaum, Sabrina Geisslinger, Gerd Zeuzem, Stefan Welsch, Christoph Lange, Christian Markus |
author_facet | Schwarzkopf, Katharina Maria Queck, Alexander Thomas, Dominique Angioni, Carlo Cai, Chengcong Freygang, Ylva Rüschenbaum, Sabrina Geisslinger, Gerd Zeuzem, Stefan Welsch, Christoph Lange, Christian Markus |
author_sort | Schwarzkopf, Katharina Maria |
collection | PubMed |
description | BACKGROUND: Liver cirrhosis is associated with profound immunodysfunction, i.e. a parallel presence of chronic systemic inflammation and immunosuppression, which can result in acute-on-chronic liver failure (ACLF). Omega-3 fatty acids are precursors of pro-resolving mediators and support the resolution of inflammation. OBJECTIVE: The aim of this study was to determine plasma levels of omega-3 fatty acids in patients with liver cirrhosis and ACLF. METHODS: Patients with liver cirrhosis with and without ACLF were enrolled in a prospective cohort study and analyzed post-hoc for the present sub-study. Clinical data and biomaterials were collected at baseline and at day 7, 28 and after 3 months of follow-up. Plasma concentrations of arachidonic acid (ARA) and docosahexaenoic acid (DHA), which represent key omega-6 and -3 fatty acids, respectively, were quantified and associated with markers of systemic inflammation and severity of liver cirrhosis. RESULTS: A total of 117 patients were included in the present analyses. Of those, 26 (22.2%), 51 (43.6%) and 40 (34.2%) patients had compensated or decompensated liver cirrhosis, and ACLF. Plasma levels of ARA and DHA were similar in patients with compensated cirrhosis, decompensated cirrhosis, and ACLF. Furthermore, no significant association between plasma ARA or DHA and C-reactive protein or peripheral blood leukocytes were observed (P>0.05). CONCLUSION: In our study plasma levels of key omega-3 and omega-6 fatty acid are neither associated with the severity of liver cirrhosis nor with liver-cirrhosis-associated systemic inflammation. |
format | Online Article Text |
id | pubmed-6355116 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-63551162019-02-15 Omega-3 and -6 fatty acid plasma levels are not associated with liver cirrhosis-associated systemic inflammation Schwarzkopf, Katharina Maria Queck, Alexander Thomas, Dominique Angioni, Carlo Cai, Chengcong Freygang, Ylva Rüschenbaum, Sabrina Geisslinger, Gerd Zeuzem, Stefan Welsch, Christoph Lange, Christian Markus PLoS One Research Article BACKGROUND: Liver cirrhosis is associated with profound immunodysfunction, i.e. a parallel presence of chronic systemic inflammation and immunosuppression, which can result in acute-on-chronic liver failure (ACLF). Omega-3 fatty acids are precursors of pro-resolving mediators and support the resolution of inflammation. OBJECTIVE: The aim of this study was to determine plasma levels of omega-3 fatty acids in patients with liver cirrhosis and ACLF. METHODS: Patients with liver cirrhosis with and without ACLF were enrolled in a prospective cohort study and analyzed post-hoc for the present sub-study. Clinical data and biomaterials were collected at baseline and at day 7, 28 and after 3 months of follow-up. Plasma concentrations of arachidonic acid (ARA) and docosahexaenoic acid (DHA), which represent key omega-6 and -3 fatty acids, respectively, were quantified and associated with markers of systemic inflammation and severity of liver cirrhosis. RESULTS: A total of 117 patients were included in the present analyses. Of those, 26 (22.2%), 51 (43.6%) and 40 (34.2%) patients had compensated or decompensated liver cirrhosis, and ACLF. Plasma levels of ARA and DHA were similar in patients with compensated cirrhosis, decompensated cirrhosis, and ACLF. Furthermore, no significant association between plasma ARA or DHA and C-reactive protein or peripheral blood leukocytes were observed (P>0.05). CONCLUSION: In our study plasma levels of key omega-3 and omega-6 fatty acid are neither associated with the severity of liver cirrhosis nor with liver-cirrhosis-associated systemic inflammation. Public Library of Science 2019-01-31 /pmc/articles/PMC6355116/ /pubmed/30703151 http://dx.doi.org/10.1371/journal.pone.0211537 Text en © 2019 Schwarzkopf et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Article Schwarzkopf, Katharina Maria Queck, Alexander Thomas, Dominique Angioni, Carlo Cai, Chengcong Freygang, Ylva Rüschenbaum, Sabrina Geisslinger, Gerd Zeuzem, Stefan Welsch, Christoph Lange, Christian Markus Omega-3 and -6 fatty acid plasma levels are not associated with liver cirrhosis-associated systemic inflammation |
title | Omega-3 and -6 fatty acid plasma levels are not associated with liver cirrhosis-associated systemic inflammation |
title_full | Omega-3 and -6 fatty acid plasma levels are not associated with liver cirrhosis-associated systemic inflammation |
title_fullStr | Omega-3 and -6 fatty acid plasma levels are not associated with liver cirrhosis-associated systemic inflammation |
title_full_unstemmed | Omega-3 and -6 fatty acid plasma levels are not associated with liver cirrhosis-associated systemic inflammation |
title_short | Omega-3 and -6 fatty acid plasma levels are not associated with liver cirrhosis-associated systemic inflammation |
title_sort | omega-3 and -6 fatty acid plasma levels are not associated with liver cirrhosis-associated systemic inflammation |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6355116/ https://www.ncbi.nlm.nih.gov/pubmed/30703151 http://dx.doi.org/10.1371/journal.pone.0211537 |
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