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Sustained response of three pediatric BRAF(V600E) mutated high-grade gliomas to combined BRAF and MEK inhibitor therapy

Outcomes for children with high-grade gliomas (HGG) remain dismal despite aggressive treatment strategies. The use of targeted therapy for BRAF(V600E) mutated malignancies including HGG is being explored as a potentially well tolerated and effective therapeutic option. The results of adult melanoma...

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Autores principales: Toll, Stephanie A., Tran, Hung N., Cotter, Jennifer, Judkins, Alexander R., Tamrazi, Benita, Biegel, Jaclyn A., Dhall, Girish, Robison, Nathan J., Waters, Kaaren, Patel, Palak, Cooper, Robert, Margol, Ashley S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6355184/
https://www.ncbi.nlm.nih.gov/pubmed/30728904
http://dx.doi.org/10.18632/oncotarget.26560
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author Toll, Stephanie A.
Tran, Hung N.
Cotter, Jennifer
Judkins, Alexander R.
Tamrazi, Benita
Biegel, Jaclyn A.
Dhall, Girish
Robison, Nathan J.
Waters, Kaaren
Patel, Palak
Cooper, Robert
Margol, Ashley S.
author_facet Toll, Stephanie A.
Tran, Hung N.
Cotter, Jennifer
Judkins, Alexander R.
Tamrazi, Benita
Biegel, Jaclyn A.
Dhall, Girish
Robison, Nathan J.
Waters, Kaaren
Patel, Palak
Cooper, Robert
Margol, Ashley S.
author_sort Toll, Stephanie A.
collection PubMed
description Outcomes for children with high-grade gliomas (HGG) remain dismal despite aggressive treatment strategies. The use of targeted therapy for BRAF(V600E) mutated malignancies including HGG is being explored as a potentially well tolerated and effective therapeutic option. The results of adult melanoma studies demonstrating that combination therapy with BRAF inhibitors and MEK inhibitors results in prolonged survival led us to employ this treatment strategy in children with BRAF(V600E) mutated HGG. In this case series, we describe three pediatric patients with HGG with confirmed BRAF(V600E) mutation who demonstrated responses to combination therapy with dabrafenib and trametinib.
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spelling pubmed-63551842019-02-06 Sustained response of three pediatric BRAF(V600E) mutated high-grade gliomas to combined BRAF and MEK inhibitor therapy Toll, Stephanie A. Tran, Hung N. Cotter, Jennifer Judkins, Alexander R. Tamrazi, Benita Biegel, Jaclyn A. Dhall, Girish Robison, Nathan J. Waters, Kaaren Patel, Palak Cooper, Robert Margol, Ashley S. Oncotarget Case Report Outcomes for children with high-grade gliomas (HGG) remain dismal despite aggressive treatment strategies. The use of targeted therapy for BRAF(V600E) mutated malignancies including HGG is being explored as a potentially well tolerated and effective therapeutic option. The results of adult melanoma studies demonstrating that combination therapy with BRAF inhibitors and MEK inhibitors results in prolonged survival led us to employ this treatment strategy in children with BRAF(V600E) mutated HGG. In this case series, we describe three pediatric patients with HGG with confirmed BRAF(V600E) mutation who demonstrated responses to combination therapy with dabrafenib and trametinib. Impact Journals LLC 2019-01-11 /pmc/articles/PMC6355184/ /pubmed/30728904 http://dx.doi.org/10.18632/oncotarget.26560 Text en Copyright: © 2019 Toll et al. http://creativecommons.org/licenses/by/3.0/ This article is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0/) (CC-BY), which permits unrestricted use and redistribution provided that the original author and source are credited.
spellingShingle Case Report
Toll, Stephanie A.
Tran, Hung N.
Cotter, Jennifer
Judkins, Alexander R.
Tamrazi, Benita
Biegel, Jaclyn A.
Dhall, Girish
Robison, Nathan J.
Waters, Kaaren
Patel, Palak
Cooper, Robert
Margol, Ashley S.
Sustained response of three pediatric BRAF(V600E) mutated high-grade gliomas to combined BRAF and MEK inhibitor therapy
title Sustained response of three pediatric BRAF(V600E) mutated high-grade gliomas to combined BRAF and MEK inhibitor therapy
title_full Sustained response of three pediatric BRAF(V600E) mutated high-grade gliomas to combined BRAF and MEK inhibitor therapy
title_fullStr Sustained response of three pediatric BRAF(V600E) mutated high-grade gliomas to combined BRAF and MEK inhibitor therapy
title_full_unstemmed Sustained response of three pediatric BRAF(V600E) mutated high-grade gliomas to combined BRAF and MEK inhibitor therapy
title_short Sustained response of three pediatric BRAF(V600E) mutated high-grade gliomas to combined BRAF and MEK inhibitor therapy
title_sort sustained response of three pediatric braf(v600e) mutated high-grade gliomas to combined braf and mek inhibitor therapy
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6355184/
https://www.ncbi.nlm.nih.gov/pubmed/30728904
http://dx.doi.org/10.18632/oncotarget.26560
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