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Structural basis of Ca(2+)-dependent activation and lipid transport by a TMEM16 scramblase

The lipid distribution of plasma membranes of eukaryotic cells is asymmetric and phospholipid scramblases disrupt this asymmetry by mediating the rapid, nonselective transport of lipids down their concentration gradients. As a result, phosphatidylserine is exposed to the outer leaflet of membrane, a...

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Detalles Bibliográficos
Autores principales:	Falzone, Maria E, Rheinberger, Jan, Lee, Byoung-Cheol, Peyear, Thasin, Sasset, Linda, Raczkowski, Ashleigh M, Eng, Edward T, Di Lorenzo, Annarita, Andersen, Olaf S, Nimigean, Crina M, Accardi, Alessio
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	eLife Sciences Publications, Ltd 2019
Materias:	Structural Biology and Molecular Biophysics
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6355197/ https://www.ncbi.nlm.nih.gov/pubmed/30648972 http://dx.doi.org/10.7554/eLife.43229

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