Coronary Artery Plaque Regression by a PCSK9 Antibody and Rosuvastatin in Double-heterozygous Familial Hypercholesterolemia with an LDL Receptor Mutation and a PCSK9 V4I Mutation

The low-density lipoprotein-cholesterol (LDL-C) level of a 38-year-old man diagnosed with acute coronary syndrome was 257 mg/dL. The administration of a proprotein convertase subtilisin-kexin type 9 (PCSK9) antibody in addition to rosuvastatin plus ezetimibe was initiated, reducing his LDL-C level t...

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Autores principales: Shirahama, Ryo, Ono, Takamichi, Nagamatsu, Suguru, Sueta, Daisuke, Takashio, Seiji, Chitose, Tadasuke, Fujisue, Koichiro, Sakamoto, Kenji, Yamamoto, Eiichiro, Izumiya, Yasuhiro, Kaikita, Koichi, Hokimoto, Seiji, Hori, Mika, Harada-Shiba, Mariko, Kajiwara, Ichiro, Ogawa, Hisao, Tsujita, Kenichi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Internal Medicine 2018
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6355420/
https://www.ncbi.nlm.nih.gov/pubmed/30555118
http://dx.doi.org/10.2169/internalmedicine.1060-18
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author Shirahama, Ryo
Ono, Takamichi
Nagamatsu, Suguru
Sueta, Daisuke
Takashio, Seiji
Chitose, Tadasuke
Fujisue, Koichiro
Sakamoto, Kenji
Yamamoto, Eiichiro
Izumiya, Yasuhiro
Kaikita, Koichi
Hokimoto, Seiji
Hori, Mika
Harada-Shiba, Mariko
Kajiwara, Ichiro
Ogawa, Hisao
Tsujita, Kenichi
author_facet Shirahama, Ryo
Ono, Takamichi
Nagamatsu, Suguru
Sueta, Daisuke
Takashio, Seiji
Chitose, Tadasuke
Fujisue, Koichiro
Sakamoto, Kenji
Yamamoto, Eiichiro
Izumiya, Yasuhiro
Kaikita, Koichi
Hokimoto, Seiji
Hori, Mika
Harada-Shiba, Mariko
Kajiwara, Ichiro
Ogawa, Hisao
Tsujita, Kenichi
author_sort Shirahama, Ryo
collection PubMed
description The low-density lipoprotein-cholesterol (LDL-C) level of a 38-year-old man diagnosed with acute coronary syndrome was 257 mg/dL. The administration of a proprotein convertase subtilisin-kexin type 9 (PCSK9) antibody in addition to rosuvastatin plus ezetimibe was initiated, reducing his LDL-C level to 37 mg/dL. A genetic analysis revealed both an LDL receptor (LDLR) mutation and a PCSK9 V4I mutation. Nine months after revascularization, intravascular ultrasound revealed plaque regression in the coronary arteries. LDLR/PCSK9 mutation carriers are prone to coronary artery disease. Intensive LDL-C lowering by including PCSK9 antibody was associated with coronary plaque regression, suggesting the expectation of prognosis improvement.
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spelling pubmed-63554202019-02-01 Coronary Artery Plaque Regression by a PCSK9 Antibody and Rosuvastatin in Double-heterozygous Familial Hypercholesterolemia with an LDL Receptor Mutation and a PCSK9 V4I Mutation Shirahama, Ryo Ono, Takamichi Nagamatsu, Suguru Sueta, Daisuke Takashio, Seiji Chitose, Tadasuke Fujisue, Koichiro Sakamoto, Kenji Yamamoto, Eiichiro Izumiya, Yasuhiro Kaikita, Koichi Hokimoto, Seiji Hori, Mika Harada-Shiba, Mariko Kajiwara, Ichiro Ogawa, Hisao Tsujita, Kenichi Intern Med Case Report The low-density lipoprotein-cholesterol (LDL-C) level of a 38-year-old man diagnosed with acute coronary syndrome was 257 mg/dL. The administration of a proprotein convertase subtilisin-kexin type 9 (PCSK9) antibody in addition to rosuvastatin plus ezetimibe was initiated, reducing his LDL-C level to 37 mg/dL. A genetic analysis revealed both an LDL receptor (LDLR) mutation and a PCSK9 V4I mutation. Nine months after revascularization, intravascular ultrasound revealed plaque regression in the coronary arteries. LDLR/PCSK9 mutation carriers are prone to coronary artery disease. Intensive LDL-C lowering by including PCSK9 antibody was associated with coronary plaque regression, suggesting the expectation of prognosis improvement. The Japanese Society of Internal Medicine 2018-12-15 /pmc/articles/PMC6355420/ /pubmed/30555118 http://dx.doi.org/10.2169/internalmedicine.1060-18 Text en Copyright © 2018 by The Japanese Society of Internal Medicine https://creativecommons.org/licenses/by-nc-nd/4.0/ The Internal Medicine is an Open Access journal distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. To view the details of this license, please visit (https://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Case Report
Shirahama, Ryo
Ono, Takamichi
Nagamatsu, Suguru
Sueta, Daisuke
Takashio, Seiji
Chitose, Tadasuke
Fujisue, Koichiro
Sakamoto, Kenji
Yamamoto, Eiichiro
Izumiya, Yasuhiro
Kaikita, Koichi
Hokimoto, Seiji
Hori, Mika
Harada-Shiba, Mariko
Kajiwara, Ichiro
Ogawa, Hisao
Tsujita, Kenichi
Coronary Artery Plaque Regression by a PCSK9 Antibody and Rosuvastatin in Double-heterozygous Familial Hypercholesterolemia with an LDL Receptor Mutation and a PCSK9 V4I Mutation
title Coronary Artery Plaque Regression by a PCSK9 Antibody and Rosuvastatin in Double-heterozygous Familial Hypercholesterolemia with an LDL Receptor Mutation and a PCSK9 V4I Mutation
title_full Coronary Artery Plaque Regression by a PCSK9 Antibody and Rosuvastatin in Double-heterozygous Familial Hypercholesterolemia with an LDL Receptor Mutation and a PCSK9 V4I Mutation
title_fullStr Coronary Artery Plaque Regression by a PCSK9 Antibody and Rosuvastatin in Double-heterozygous Familial Hypercholesterolemia with an LDL Receptor Mutation and a PCSK9 V4I Mutation
title_full_unstemmed Coronary Artery Plaque Regression by a PCSK9 Antibody and Rosuvastatin in Double-heterozygous Familial Hypercholesterolemia with an LDL Receptor Mutation and a PCSK9 V4I Mutation
title_short Coronary Artery Plaque Regression by a PCSK9 Antibody and Rosuvastatin in Double-heterozygous Familial Hypercholesterolemia with an LDL Receptor Mutation and a PCSK9 V4I Mutation
title_sort coronary artery plaque regression by a pcsk9 antibody and rosuvastatin in double-heterozygous familial hypercholesterolemia with an ldl receptor mutation and a pcsk9 v4i mutation
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6355420/
https://www.ncbi.nlm.nih.gov/pubmed/30555118
http://dx.doi.org/10.2169/internalmedicine.1060-18
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