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Fibrolamellar Hepatocellular Carcinoma with Multiple Lung Metastases Treated with Multidisciplinary Therapy
A 20-year old man was diagnosed with fibrolamellar hepatocellular carcinoma (FLHCC) with multiple lung metastases, and chemotherapy with FOLFOX was administered. Contrast enhanced CT after 3 cycles of FOLFOX showed no disease progression. We therefore performed surgical resection and radiofrequency...
| Autores principales: | , , , , , , , , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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The Japanese Society of Internal Medicine
2018
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6355421/ https://www.ncbi.nlm.nih.gov/pubmed/30101933 http://dx.doi.org/10.2169/internalmedicine.1243-18 |
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| author | Tanaka, Hiroki Hijioka, Susumu Iwaya, Hiromichi Mizuno, Nobumasa Kuwahara, Takamichi Okuno, Nozomi Ito, Ayako Kuraoka, Naosuke Matsumoto, Shinpei Obata, Masahiro Kurita, Yusuke Yasuda, Muneji Shimizu, Yasuhiro Kuroda, Hiroaki Sato, Yozo Haneda, Masataka Sasaki, Eiichi Yatabe, Yasushi Hara, Kazuo |
| author_facet | Tanaka, Hiroki Hijioka, Susumu Iwaya, Hiromichi Mizuno, Nobumasa Kuwahara, Takamichi Okuno, Nozomi Ito, Ayako Kuraoka, Naosuke Matsumoto, Shinpei Obata, Masahiro Kurita, Yusuke Yasuda, Muneji Shimizu, Yasuhiro Kuroda, Hiroaki Sato, Yozo Haneda, Masataka Sasaki, Eiichi Yatabe, Yasushi Hara, Kazuo |
| author_sort | Tanaka, Hiroki |
| collection | PubMed |
| description | A 20-year old man was diagnosed with fibrolamellar hepatocellular carcinoma (FLHCC) with multiple lung metastases, and chemotherapy with FOLFOX was administered. Contrast enhanced CT after 3 cycles of FOLFOX showed no disease progression. We therefore performed surgical resection and radiofrequency ablation of the liver lesions and lung metastases, after obtaining the patient's informed consent. The liver lesions and lung metastases tested positive for DNAJB1-PRKACA. The treatment for FLHCC with extrahepatic metastasis has not been established; however, in a few cases, good long-term prognoses were obtained with multidisciplinary therapy. We herein report a case of FLHCC with multiple lung metastases that was treated with multidisciplinary therapies. |
| format | Online Article Text |
| id | pubmed-6355421 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2018 |
| publisher | The Japanese Society of Internal Medicine |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-63554212019-02-01 Fibrolamellar Hepatocellular Carcinoma with Multiple Lung Metastases Treated with Multidisciplinary Therapy Tanaka, Hiroki Hijioka, Susumu Iwaya, Hiromichi Mizuno, Nobumasa Kuwahara, Takamichi Okuno, Nozomi Ito, Ayako Kuraoka, Naosuke Matsumoto, Shinpei Obata, Masahiro Kurita, Yusuke Yasuda, Muneji Shimizu, Yasuhiro Kuroda, Hiroaki Sato, Yozo Haneda, Masataka Sasaki, Eiichi Yatabe, Yasushi Hara, Kazuo Intern Med Case Report A 20-year old man was diagnosed with fibrolamellar hepatocellular carcinoma (FLHCC) with multiple lung metastases, and chemotherapy with FOLFOX was administered. Contrast enhanced CT after 3 cycles of FOLFOX showed no disease progression. We therefore performed surgical resection and radiofrequency ablation of the liver lesions and lung metastases, after obtaining the patient's informed consent. The liver lesions and lung metastases tested positive for DNAJB1-PRKACA. The treatment for FLHCC with extrahepatic metastasis has not been established; however, in a few cases, good long-term prognoses were obtained with multidisciplinary therapy. We herein report a case of FLHCC with multiple lung metastases that was treated with multidisciplinary therapies. The Japanese Society of Internal Medicine 2018-08-10 2018-12-15 /pmc/articles/PMC6355421/ /pubmed/30101933 http://dx.doi.org/10.2169/internalmedicine.1243-18 Text en Copyright © 2018 by The Japanese Society of Internal Medicine https://creativecommons.org/licenses/by-nc-nd/4.0/ The Internal Medicine is an Open Access journal distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. To view the details of this license, please visit (https://creativecommons.org/licenses/by-nc-nd/4.0/). |
| spellingShingle | Case Report Tanaka, Hiroki Hijioka, Susumu Iwaya, Hiromichi Mizuno, Nobumasa Kuwahara, Takamichi Okuno, Nozomi Ito, Ayako Kuraoka, Naosuke Matsumoto, Shinpei Obata, Masahiro Kurita, Yusuke Yasuda, Muneji Shimizu, Yasuhiro Kuroda, Hiroaki Sato, Yozo Haneda, Masataka Sasaki, Eiichi Yatabe, Yasushi Hara, Kazuo Fibrolamellar Hepatocellular Carcinoma with Multiple Lung Metastases Treated with Multidisciplinary Therapy |
| title | Fibrolamellar Hepatocellular Carcinoma with Multiple Lung Metastases Treated with Multidisciplinary Therapy |
| title_full | Fibrolamellar Hepatocellular Carcinoma with Multiple Lung Metastases Treated with Multidisciplinary Therapy |
| title_fullStr | Fibrolamellar Hepatocellular Carcinoma with Multiple Lung Metastases Treated with Multidisciplinary Therapy |
| title_full_unstemmed | Fibrolamellar Hepatocellular Carcinoma with Multiple Lung Metastases Treated with Multidisciplinary Therapy |
| title_short | Fibrolamellar Hepatocellular Carcinoma with Multiple Lung Metastases Treated with Multidisciplinary Therapy |
| title_sort | fibrolamellar hepatocellular carcinoma with multiple lung metastases treated with multidisciplinary therapy |
| topic | Case Report |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6355421/ https://www.ncbi.nlm.nih.gov/pubmed/30101933 http://dx.doi.org/10.2169/internalmedicine.1243-18 |
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