Anti-HLA antibodies with complementary and synergistic interaction geometries promote classical complement activation on platelets

High titers of HLA antibodies are associated with platelet refractoriness, causing poor platelet increments after transfusions in a subset of patients with HLA antibodies. Currently, we do not know the biological mechanisms that explain the variability in clinical responses in HLA alloimmunized pati...

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Detalles Bibliográficos
Autores principales: Rijkers, Maaike, Schmidt, David, Lu, Nina, Kramer, Cynthia S.M., Heidt, Sebastiaan, Mulder, Arend, Porcelijn, Leendert, Claas, Frans H.J., Leebeek, Frank W.G., Jansen, A.J. Gerard, Jongerius, Ilse, Zeerleder, Sacha S., Vidarsson, Gestur, Voorberg, Jan, de Haas, Masja
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ferrata Storti Foundation 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6355480/
https://www.ncbi.nlm.nih.gov/pubmed/30262558
http://dx.doi.org/10.3324/haematol.2018.201665

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