Targeting glutaminase 1 attenuates stemness properties in hepatocellular carcinoma by increasing reactive oxygen species and suppressing Wnt/beta-catenin pathway

BACKGROUND: Hepatocellular carcinoma (HCC) is an aggressive malignant disease with poor prognosis. Recent advances suggest the existence of cancer stem cells (CSCs) within liver cancer, which are considered to be responsible for tumor relapse, metastasis, and chemoresistance. However, novel therapeu...

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Detalles Bibliográficos
Autores principales: Li, Binghua, Cao, Yajuan, Meng, Gang, Qian, Liyuan, Xu, Tiancheng, Yan, Chen, Luo, Ouyang, Wang, Shaohe, Wei, Jiwu, Ding, Yitao, Yu, Decai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2018
Materias:
Research paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6355660/
https://www.ncbi.nlm.nih.gov/pubmed/30555042
http://dx.doi.org/10.1016/j.ebiom.2018.11.063

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