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Reaction to Endoplasmic Reticulum Stress via ATF6 in Amyotrophic Lateral Sclerosis Deteriorates With Aging

Amyotrophic lateral sclerosis (ALS) is a multisystemic neurodegenerative disorder. Given that peripheral blood mononuclear cells (PBMCs) serve as a “window to the central nervous system” we aimed to answer whether endoplasmic reticulum (ER) stress in ALS-PBMCs is related to disease aggressiveness. W...

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Detalles Bibliográficos
Autores principales:	Prell, Tino, Stubendorff, Beatrice, Le, Thanh Tu, Gaur, Nayana, Tadić, Vedrana, Rödiger, Annekathrin, Witte, Otto W., Grosskreutz, Julian
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2019
Materias:	Neuroscience
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6355670/ https://www.ncbi.nlm.nih.gov/pubmed/30740050 http://dx.doi.org/10.3389/fnagi.2019.00005

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