Biventricular Increases in Mitochondrial Fission Mediator (MiD51) and Proglycolytic Pyruvate Kinase (PKM2) Isoform in Experimental Group 2 Pulmonary Hypertension-Novel Mitochondrial Abnormalities

Introduction: Group 2 pulmonary hypertension (PH), defined as a mean pulmonary arterial pressure ≥25 mmHg with elevated pulmonary capillary wedge pressure >15 mmHg, has no approved therapy and patients often die from right ventricular failure (RVF). Alterations in mitochondrial metabolism, notabl...

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Detalles Bibliográficos
Autores principales: Xiong, Ping Yu, Tian, Lian, Dunham-Snary, Kimberly J., Chen, Kuang-Hueih, Mewburn, Jeffrey D., Neuber-Hess, Monica, Martin, Ashley, Dasgupta, Asish, Potus, Francois, Archer, Stephen L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Cardiovascular Medicine
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6355690/
https://www.ncbi.nlm.nih.gov/pubmed/30740395
http://dx.doi.org/10.3389/fcvm.2018.00195

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