The TYK2-P1104A Autoimmune Protective Variant Limits Coordinate Signals Required to Generate Specialized T Cell Subsets

TYK2 is a JAK family member that functions downstream of multiple cytokine receptors. Genome wide association studies have linked a SNP (rs34536443) within TYK2 encoding a Proline to Alanine substitution at amino acid 1104, to protection from multiple autoimmune diseases including systemic lupus ery...

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Detalles Bibliográficos
Autores principales: Gorman, Jacquelyn A., Hundhausen, Christian, Kinsman, Mackenzie, Arkatkar, Tanvi, Allenspach, Eric J., Clough, Courtnee, West, Samuel E., Thomas, Kerri, Eken, Ahmet, Khim, Socheath, Hale, Malika, Oukka, Mohamed, Jackson, Shaun W., Cerosaletti, Karen, Buckner, Jane H., Rawlings, David J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6355696/
https://www.ncbi.nlm.nih.gov/pubmed/30740104
http://dx.doi.org/10.3389/fimmu.2019.00044

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