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Identification of recurrent fusion genes across multiple cancer types
Chromosome changes are one of the hallmarks of human malignancies. Chromosomal rearrangement is frequent in human cancers. One of the consequences of chromosomal rearrangement is gene fusions in the cancer genome. We have previously identified a panel of fusion genes in aggressive prostate cancers....
Autores principales: | , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6355770/ https://www.ncbi.nlm.nih.gov/pubmed/30705370 http://dx.doi.org/10.1038/s41598-019-38550-6 |
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author | Yu, Yan-Ping Liu, Peng Nelson, Joel Hamilton, Ronald L. Bhargava, Rohit Michalopoulos, George Chen, Qi Zhang, Jun Ma, Deqin Pennathur, Arjun Luketich, James Nalesnik, Michael Tseng, George Luo, Jian-Hua |
author_facet | Yu, Yan-Ping Liu, Peng Nelson, Joel Hamilton, Ronald L. Bhargava, Rohit Michalopoulos, George Chen, Qi Zhang, Jun Ma, Deqin Pennathur, Arjun Luketich, James Nalesnik, Michael Tseng, George Luo, Jian-Hua |
author_sort | Yu, Yan-Ping |
collection | PubMed |
description | Chromosome changes are one of the hallmarks of human malignancies. Chromosomal rearrangement is frequent in human cancers. One of the consequences of chromosomal rearrangement is gene fusions in the cancer genome. We have previously identified a panel of fusion genes in aggressive prostate cancers. In this study, we showed that 6 of these fusion genes are present in 7 different types of human malignancies with variable frequencies. Among them, the CCNH-C5orf30 and TRMT11-GRIK2 gene fusions were found in breast cancer, colon cancer, non-small cell lung cancer, esophageal adenocarcinoma, glioblastoma multiforme, ovarian cancer and liver cancer, with frequencies ranging from 12.9% to 85%. In contrast, four other gene fusions (mTOR-TP53BP1, TMEM135-CCDC67, KDM4-AC011523.2 and LRRC59-FLJ60017) are less frequent. Both TRMT11-GRIK2 and CCNH-C5orf30 are also frequently present in lymph node metastatic cancer samples from the breast, colon and ovary. Thus, detecting these fusion transcripts may have significant biological and clinical implications in cancer patient management. |
format | Online Article Text |
id | pubmed-6355770 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-63557702019-02-01 Identification of recurrent fusion genes across multiple cancer types Yu, Yan-Ping Liu, Peng Nelson, Joel Hamilton, Ronald L. Bhargava, Rohit Michalopoulos, George Chen, Qi Zhang, Jun Ma, Deqin Pennathur, Arjun Luketich, James Nalesnik, Michael Tseng, George Luo, Jian-Hua Sci Rep Article Chromosome changes are one of the hallmarks of human malignancies. Chromosomal rearrangement is frequent in human cancers. One of the consequences of chromosomal rearrangement is gene fusions in the cancer genome. We have previously identified a panel of fusion genes in aggressive prostate cancers. In this study, we showed that 6 of these fusion genes are present in 7 different types of human malignancies with variable frequencies. Among them, the CCNH-C5orf30 and TRMT11-GRIK2 gene fusions were found in breast cancer, colon cancer, non-small cell lung cancer, esophageal adenocarcinoma, glioblastoma multiforme, ovarian cancer and liver cancer, with frequencies ranging from 12.9% to 85%. In contrast, four other gene fusions (mTOR-TP53BP1, TMEM135-CCDC67, KDM4-AC011523.2 and LRRC59-FLJ60017) are less frequent. Both TRMT11-GRIK2 and CCNH-C5orf30 are also frequently present in lymph node metastatic cancer samples from the breast, colon and ovary. Thus, detecting these fusion transcripts may have significant biological and clinical implications in cancer patient management. Nature Publishing Group UK 2019-01-31 /pmc/articles/PMC6355770/ /pubmed/30705370 http://dx.doi.org/10.1038/s41598-019-38550-6 Text en © The Author(s) 2019 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Article Yu, Yan-Ping Liu, Peng Nelson, Joel Hamilton, Ronald L. Bhargava, Rohit Michalopoulos, George Chen, Qi Zhang, Jun Ma, Deqin Pennathur, Arjun Luketich, James Nalesnik, Michael Tseng, George Luo, Jian-Hua Identification of recurrent fusion genes across multiple cancer types |
title | Identification of recurrent fusion genes across multiple cancer types |
title_full | Identification of recurrent fusion genes across multiple cancer types |
title_fullStr | Identification of recurrent fusion genes across multiple cancer types |
title_full_unstemmed | Identification of recurrent fusion genes across multiple cancer types |
title_short | Identification of recurrent fusion genes across multiple cancer types |
title_sort | identification of recurrent fusion genes across multiple cancer types |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6355770/ https://www.ncbi.nlm.nih.gov/pubmed/30705370 http://dx.doi.org/10.1038/s41598-019-38550-6 |
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