Cargando…

Identification of recurrent fusion genes across multiple cancer types

Chromosome changes are one of the hallmarks of human malignancies. Chromosomal rearrangement is frequent in human cancers. One of the consequences of chromosomal rearrangement is gene fusions in the cancer genome. We have previously identified a panel of fusion genes in aggressive prostate cancers....

Descripción completa

Detalles Bibliográficos
Autores principales: Yu, Yan-Ping, Liu, Peng, Nelson, Joel, Hamilton, Ronald L., Bhargava, Rohit, Michalopoulos, George, Chen, Qi, Zhang, Jun, Ma, Deqin, Pennathur, Arjun, Luketich, James, Nalesnik, Michael, Tseng, George, Luo, Jian-Hua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6355770/
https://www.ncbi.nlm.nih.gov/pubmed/30705370
http://dx.doi.org/10.1038/s41598-019-38550-6
_version_ 1783391384050335744
author Yu, Yan-Ping
Liu, Peng
Nelson, Joel
Hamilton, Ronald L.
Bhargava, Rohit
Michalopoulos, George
Chen, Qi
Zhang, Jun
Ma, Deqin
Pennathur, Arjun
Luketich, James
Nalesnik, Michael
Tseng, George
Luo, Jian-Hua
author_facet Yu, Yan-Ping
Liu, Peng
Nelson, Joel
Hamilton, Ronald L.
Bhargava, Rohit
Michalopoulos, George
Chen, Qi
Zhang, Jun
Ma, Deqin
Pennathur, Arjun
Luketich, James
Nalesnik, Michael
Tseng, George
Luo, Jian-Hua
author_sort Yu, Yan-Ping
collection PubMed
description Chromosome changes are one of the hallmarks of human malignancies. Chromosomal rearrangement is frequent in human cancers. One of the consequences of chromosomal rearrangement is gene fusions in the cancer genome. We have previously identified a panel of fusion genes in aggressive prostate cancers. In this study, we showed that 6 of these fusion genes are present in 7 different types of human malignancies with variable frequencies. Among them, the CCNH-C5orf30 and TRMT11-GRIK2 gene fusions were found in breast cancer, colon cancer, non-small cell lung cancer, esophageal adenocarcinoma, glioblastoma multiforme, ovarian cancer and liver cancer, with frequencies ranging from 12.9% to 85%. In contrast, four other gene fusions (mTOR-TP53BP1, TMEM135-CCDC67, KDM4-AC011523.2 and LRRC59-FLJ60017) are less frequent. Both TRMT11-GRIK2 and CCNH-C5orf30 are also frequently present in lymph node metastatic cancer samples from the breast, colon and ovary. Thus, detecting these fusion transcripts may have significant biological and clinical implications in cancer patient management.
format Online
Article
Text
id pubmed-6355770
institution National Center for Biotechnology Information
language English
publishDate 2019
publisher Nature Publishing Group UK
record_format MEDLINE/PubMed
spelling pubmed-63557702019-02-01 Identification of recurrent fusion genes across multiple cancer types Yu, Yan-Ping Liu, Peng Nelson, Joel Hamilton, Ronald L. Bhargava, Rohit Michalopoulos, George Chen, Qi Zhang, Jun Ma, Deqin Pennathur, Arjun Luketich, James Nalesnik, Michael Tseng, George Luo, Jian-Hua Sci Rep Article Chromosome changes are one of the hallmarks of human malignancies. Chromosomal rearrangement is frequent in human cancers. One of the consequences of chromosomal rearrangement is gene fusions in the cancer genome. We have previously identified a panel of fusion genes in aggressive prostate cancers. In this study, we showed that 6 of these fusion genes are present in 7 different types of human malignancies with variable frequencies. Among them, the CCNH-C5orf30 and TRMT11-GRIK2 gene fusions were found in breast cancer, colon cancer, non-small cell lung cancer, esophageal adenocarcinoma, glioblastoma multiforme, ovarian cancer and liver cancer, with frequencies ranging from 12.9% to 85%. In contrast, four other gene fusions (mTOR-TP53BP1, TMEM135-CCDC67, KDM4-AC011523.2 and LRRC59-FLJ60017) are less frequent. Both TRMT11-GRIK2 and CCNH-C5orf30 are also frequently present in lymph node metastatic cancer samples from the breast, colon and ovary. Thus, detecting these fusion transcripts may have significant biological and clinical implications in cancer patient management. Nature Publishing Group UK 2019-01-31 /pmc/articles/PMC6355770/ /pubmed/30705370 http://dx.doi.org/10.1038/s41598-019-38550-6 Text en © The Author(s) 2019 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Yu, Yan-Ping
Liu, Peng
Nelson, Joel
Hamilton, Ronald L.
Bhargava, Rohit
Michalopoulos, George
Chen, Qi
Zhang, Jun
Ma, Deqin
Pennathur, Arjun
Luketich, James
Nalesnik, Michael
Tseng, George
Luo, Jian-Hua
Identification of recurrent fusion genes across multiple cancer types
title Identification of recurrent fusion genes across multiple cancer types
title_full Identification of recurrent fusion genes across multiple cancer types
title_fullStr Identification of recurrent fusion genes across multiple cancer types
title_full_unstemmed Identification of recurrent fusion genes across multiple cancer types
title_short Identification of recurrent fusion genes across multiple cancer types
title_sort identification of recurrent fusion genes across multiple cancer types
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6355770/
https://www.ncbi.nlm.nih.gov/pubmed/30705370
http://dx.doi.org/10.1038/s41598-019-38550-6
work_keys_str_mv AT yuyanping identificationofrecurrentfusiongenesacrossmultiplecancertypes
AT liupeng identificationofrecurrentfusiongenesacrossmultiplecancertypes
AT nelsonjoel identificationofrecurrentfusiongenesacrossmultiplecancertypes
AT hamiltonronaldl identificationofrecurrentfusiongenesacrossmultiplecancertypes
AT bhargavarohit identificationofrecurrentfusiongenesacrossmultiplecancertypes
AT michalopoulosgeorge identificationofrecurrentfusiongenesacrossmultiplecancertypes
AT chenqi identificationofrecurrentfusiongenesacrossmultiplecancertypes
AT zhangjun identificationofrecurrentfusiongenesacrossmultiplecancertypes
AT madeqin identificationofrecurrentfusiongenesacrossmultiplecancertypes
AT pennathurarjun identificationofrecurrentfusiongenesacrossmultiplecancertypes
AT luketichjames identificationofrecurrentfusiongenesacrossmultiplecancertypes
AT nalesnikmichael identificationofrecurrentfusiongenesacrossmultiplecancertypes
AT tsenggeorge identificationofrecurrentfusiongenesacrossmultiplecancertypes
AT luojianhua identificationofrecurrentfusiongenesacrossmultiplecancertypes