pAKT pathway activation is associated with PIK3CA mutations and good prognosis in luminal breast cancer in contrast to p-mTOR pathway activation

Numerous studies have focused on the PI3K/AKT/mTOR pathway in estrogen receptor positive (ER) breast cancer (BC), as a linear signal transduction pathway and reported its association with worse clinical outcomes. We developed gene signatures that reflect the level of expression of phosphorylated-Ser...

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Detalles Bibliográficos
Autores principales: Sonnenblick, Amir, Venet, David, Brohée, Sylvain, Pondé, Noam, Sotiriou, Christos
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6355773/
https://www.ncbi.nlm.nih.gov/pubmed/30729154
http://dx.doi.org/10.1038/s41523-019-0102-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6355773/
https://www.ncbi.nlm.nih.gov/pubmed/30729154
http://dx.doi.org/10.1038/s41523-019-0102-1

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