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A Facile Approach to Fabricate Dual Purpose Hybrid Materials for Tissue Engineering and Water Remediation

Creating hybrid materials with multifunctionality and robust mechanical stability from natural resources is a challenging proposition in materials science. Here, we report the scalable synthesis of hybrid collagen scaffolds using collagen extracted from leather industry wastes and sago starch derive...

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Autores principales: Kalirajan, Cheirmadurai, Hameed, Pearlin, Subbiah, Nagaraj, Palanisamy, Thanikaivelan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6355841/
https://www.ncbi.nlm.nih.gov/pubmed/30705331
http://dx.doi.org/10.1038/s41598-018-37758-2
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author Kalirajan, Cheirmadurai
Hameed, Pearlin
Subbiah, Nagaraj
Palanisamy, Thanikaivelan
author_facet Kalirajan, Cheirmadurai
Hameed, Pearlin
Subbiah, Nagaraj
Palanisamy, Thanikaivelan
author_sort Kalirajan, Cheirmadurai
collection PubMed
description Creating hybrid materials with multifunctionality and robust mechanical stability from natural resources is a challenging proposition in materials science. Here, we report the scalable synthesis of hybrid collagen scaffolds using collagen extracted from leather industry wastes and sago starch derived from agro-industry. The hybrid scaffolds were incorporated with TiO(2) nanoparticles and cross-linked with oxidized sago starch. The biocompatibility, thermal stability and antimicrobial property of hybrid scaffold enabled its application in burn wound healing demonstrated through albino rat models. The highly porous hybrid scaffolds are shown to be super-compressible, which is typically forbidden in materials of biological origin. We demonstrate that the hybrid scaffolds concurrently display both adsorption and absorption behavior in the removal of oil and dye molecules, respectively from contaminated water. This study paves the way for the development of novel multifunctional and shape recoverable hybrid materials specifically from renewable resources.
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spelling pubmed-63558412019-02-01 A Facile Approach to Fabricate Dual Purpose Hybrid Materials for Tissue Engineering and Water Remediation Kalirajan, Cheirmadurai Hameed, Pearlin Subbiah, Nagaraj Palanisamy, Thanikaivelan Sci Rep Article Creating hybrid materials with multifunctionality and robust mechanical stability from natural resources is a challenging proposition in materials science. Here, we report the scalable synthesis of hybrid collagen scaffolds using collagen extracted from leather industry wastes and sago starch derived from agro-industry. The hybrid scaffolds were incorporated with TiO(2) nanoparticles and cross-linked with oxidized sago starch. The biocompatibility, thermal stability and antimicrobial property of hybrid scaffold enabled its application in burn wound healing demonstrated through albino rat models. The highly porous hybrid scaffolds are shown to be super-compressible, which is typically forbidden in materials of biological origin. We demonstrate that the hybrid scaffolds concurrently display both adsorption and absorption behavior in the removal of oil and dye molecules, respectively from contaminated water. This study paves the way for the development of novel multifunctional and shape recoverable hybrid materials specifically from renewable resources. Nature Publishing Group UK 2019-01-31 /pmc/articles/PMC6355841/ /pubmed/30705331 http://dx.doi.org/10.1038/s41598-018-37758-2 Text en © The Author(s) 2019 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Kalirajan, Cheirmadurai
Hameed, Pearlin
Subbiah, Nagaraj
Palanisamy, Thanikaivelan
A Facile Approach to Fabricate Dual Purpose Hybrid Materials for Tissue Engineering and Water Remediation
title A Facile Approach to Fabricate Dual Purpose Hybrid Materials for Tissue Engineering and Water Remediation
title_full A Facile Approach to Fabricate Dual Purpose Hybrid Materials for Tissue Engineering and Water Remediation
title_fullStr A Facile Approach to Fabricate Dual Purpose Hybrid Materials for Tissue Engineering and Water Remediation
title_full_unstemmed A Facile Approach to Fabricate Dual Purpose Hybrid Materials for Tissue Engineering and Water Remediation
title_short A Facile Approach to Fabricate Dual Purpose Hybrid Materials for Tissue Engineering and Water Remediation
title_sort facile approach to fabricate dual purpose hybrid materials for tissue engineering and water remediation
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6355841/
https://www.ncbi.nlm.nih.gov/pubmed/30705331
http://dx.doi.org/10.1038/s41598-018-37758-2
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