Cargando…
Discovering highly selective and diverse PPAR-delta agonists by ligand based machine learning and structural modeling
PPAR-δ agonists are known to enhance fatty acid metabolism, preserving glucose and physical endurance and are suggested as candidates for treating metabolic diseases. None have reached the clinic yet. Our Machine Learning algorithm called “Iterative Stochastic Elimination” (ISE) was applied to const...
| Autores principales: | , , , , , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2019
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6355875/ https://www.ncbi.nlm.nih.gov/pubmed/30705343 http://dx.doi.org/10.1038/s41598-019-38508-8 |