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Promoter-proximal pausing mediated by the exon junction complex regulates splicing

Promoter-proximal pausing of RNA polymerase II (Pol II) is a widespread transcriptional regulatory step across metazoans. Here we find that the nuclear exon junction complex (pre-EJC) is a critical and conserved regulator of this process. Depletion of pre-EJC subunits leads to a global decrease in P...

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Detalles Bibliográficos
Autores principales:	Akhtar, Junaid, Kreim, Nastasja, Marini, Federico, Mohana, Giriram, Brüne, Daniel, Binder, Harald, Roignant, Jean-Yves
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6355915/ https://www.ncbi.nlm.nih.gov/pubmed/30705266 http://dx.doi.org/10.1038/s41467-019-08381-0

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