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Anticancer polymers designed for killing dormant prostate cancer cells

The discovery of anticancer therapeutics effective in eliminating dormant cells is a significant challenge in cancer biology. Here, we describe new synthetic polymer-based anticancer agents that mimic the mode of action of anticancer peptides. These anticancer polymers developed here are designed to...

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Autores principales: Takahashi, Haruko, Yumoto, Kenji, Yasuhara, Kazuma, Nadres, Enrico T., Kikuchi, Yutaka, Buttitta, Laura, Taichman, Russell S., Kuroda, Kenichi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6355926/
https://www.ncbi.nlm.nih.gov/pubmed/30705336
http://dx.doi.org/10.1038/s41598-018-36608-5
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author Takahashi, Haruko
Yumoto, Kenji
Yasuhara, Kazuma
Nadres, Enrico T.
Kikuchi, Yutaka
Buttitta, Laura
Taichman, Russell S.
Kuroda, Kenichi
author_facet Takahashi, Haruko
Yumoto, Kenji
Yasuhara, Kazuma
Nadres, Enrico T.
Kikuchi, Yutaka
Buttitta, Laura
Taichman, Russell S.
Kuroda, Kenichi
author_sort Takahashi, Haruko
collection PubMed
description The discovery of anticancer therapeutics effective in eliminating dormant cells is a significant challenge in cancer biology. Here, we describe new synthetic polymer-based anticancer agents that mimic the mode of action of anticancer peptides. These anticancer polymers developed here are designed to capture the cationic, amphiphilic traits of anticancer peptides. The anticancer polymers are designed to target anionic lipids exposed on the cancer cell surfaces and act by disrupting the cancer cell membranes. Because the polymer mechanism is not dependent on cell proliferation, we hypothesized that the polymers were active against dormant cancer cells. The polymers exhibited cytotoxicity to proliferating prostate cancer. Importantly, the polymer killed dormant prostate cancer cells that were resistant to docetaxel. This study demonstrates a new approach to discover novel anticancer therapeutics.
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spelling pubmed-63559262019-02-04 Anticancer polymers designed for killing dormant prostate cancer cells Takahashi, Haruko Yumoto, Kenji Yasuhara, Kazuma Nadres, Enrico T. Kikuchi, Yutaka Buttitta, Laura Taichman, Russell S. Kuroda, Kenichi Sci Rep Article The discovery of anticancer therapeutics effective in eliminating dormant cells is a significant challenge in cancer biology. Here, we describe new synthetic polymer-based anticancer agents that mimic the mode of action of anticancer peptides. These anticancer polymers developed here are designed to capture the cationic, amphiphilic traits of anticancer peptides. The anticancer polymers are designed to target anionic lipids exposed on the cancer cell surfaces and act by disrupting the cancer cell membranes. Because the polymer mechanism is not dependent on cell proliferation, we hypothesized that the polymers were active against dormant cancer cells. The polymers exhibited cytotoxicity to proliferating prostate cancer. Importantly, the polymer killed dormant prostate cancer cells that were resistant to docetaxel. This study demonstrates a new approach to discover novel anticancer therapeutics. Nature Publishing Group UK 2019-01-31 /pmc/articles/PMC6355926/ /pubmed/30705336 http://dx.doi.org/10.1038/s41598-018-36608-5 Text en © The Author(s) 2019 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Takahashi, Haruko
Yumoto, Kenji
Yasuhara, Kazuma
Nadres, Enrico T.
Kikuchi, Yutaka
Buttitta, Laura
Taichman, Russell S.
Kuroda, Kenichi
Anticancer polymers designed for killing dormant prostate cancer cells
title Anticancer polymers designed for killing dormant prostate cancer cells
title_full Anticancer polymers designed for killing dormant prostate cancer cells
title_fullStr Anticancer polymers designed for killing dormant prostate cancer cells
title_full_unstemmed Anticancer polymers designed for killing dormant prostate cancer cells
title_short Anticancer polymers designed for killing dormant prostate cancer cells
title_sort anticancer polymers designed for killing dormant prostate cancer cells
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6355926/
https://www.ncbi.nlm.nih.gov/pubmed/30705336
http://dx.doi.org/10.1038/s41598-018-36608-5
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