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Volume expansion and TRPV4 activation regulate stem cell fate in three-dimensional microenvironments

For mesenchymal stem cells (MSCs) cultured in three dimensional matrices, matrix remodeling is associated with enhanced osteogenic differentiation. However, the mechanism linking matrix remodeling in 3D to osteogenesis of MSCs remains unclear. Here, we find that MSCs in viscoelastic hydrogels exhibi...

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Detalles Bibliográficos
Autores principales:	Lee, Hong-pyo, Stowers, Ryan, Chaudhuri, Ovijit
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6355972/ https://www.ncbi.nlm.nih.gov/pubmed/30705265 http://dx.doi.org/10.1038/s41467-019-08465-x

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