Patients with sickle-cell disease exhibit greater functional connectivity and centrality in the locus coeruleus compared to anemic controls

• Patients with sickle-cell disease (SCD) have greater resting-state functional connectivity between the locus coeruleus (LC) and dorsolateral prefrontal cortex (dlPFC). • Patients with SCD have greater resting state centrality of the LC; • SCD patients with chronic pain exhibited even greater funct...

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Detalles Bibliográficos
Autores principales: Bhatt, Ravi R., Zeltzer, Lonnie K., Coloigner, Julie, Wood, John C., Coates, Tom D., Labus, Jennifer S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2019
Materias:
Regular Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6356008/
https://www.ncbi.nlm.nih.gov/pubmed/30690419
http://dx.doi.org/10.1016/j.nicl.2019.101686
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author Bhatt, Ravi R.
Zeltzer, Lonnie K.
Coloigner, Julie
Wood, John C.
Coates, Tom D.
Labus, Jennifer S.
author_facet Bhatt, Ravi R.
Zeltzer, Lonnie K.
Coloigner, Julie
Wood, John C.
Coates, Tom D.
Labus, Jennifer S.
author_sort Bhatt, Ravi R.
collection PubMed
description • Patients with sickle-cell disease (SCD) have greater resting-state functional connectivity between the locus coeruleus (LC) and dorsolateral prefrontal cortex (dlPFC). • Patients with SCD have greater resting state centrality of the LC; • SCD patients with chronic pain exhibited even greater functional connectivity between the LC and dlPFC. • This study supports hyper-connectivity between the LC and PFC is a potential chronic pain generator.
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spelling pubmed-63560082019-02-08 Patients with sickle-cell disease exhibit greater functional connectivity and centrality in the locus coeruleus compared to anemic controls Bhatt, Ravi R. Zeltzer, Lonnie K. Coloigner, Julie Wood, John C. Coates, Tom D. Labus, Jennifer S. Neuroimage Clin Regular Article • Patients with sickle-cell disease (SCD) have greater resting-state functional connectivity between the locus coeruleus (LC) and dorsolateral prefrontal cortex (dlPFC). • Patients with SCD have greater resting state centrality of the LC; • SCD patients with chronic pain exhibited even greater functional connectivity between the LC and dlPFC. • This study supports hyper-connectivity between the LC and PFC is a potential chronic pain generator. Elsevier 2019-01-22 /pmc/articles/PMC6356008/ /pubmed/30690419 http://dx.doi.org/10.1016/j.nicl.2019.101686 Text en © 2019 The Authors http://creativecommons.org/licenses/by/4.0/ This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Regular Article
Bhatt, Ravi R.
Zeltzer, Lonnie K.
Coloigner, Julie
Wood, John C.
Coates, Tom D.
Labus, Jennifer S.
Patients with sickle-cell disease exhibit greater functional connectivity and centrality in the locus coeruleus compared to anemic controls
title Patients with sickle-cell disease exhibit greater functional connectivity and centrality in the locus coeruleus compared to anemic controls
title_full Patients with sickle-cell disease exhibit greater functional connectivity and centrality in the locus coeruleus compared to anemic controls
title_fullStr Patients with sickle-cell disease exhibit greater functional connectivity and centrality in the locus coeruleus compared to anemic controls
title_full_unstemmed Patients with sickle-cell disease exhibit greater functional connectivity and centrality in the locus coeruleus compared to anemic controls
title_short Patients with sickle-cell disease exhibit greater functional connectivity and centrality in the locus coeruleus compared to anemic controls
title_sort patients with sickle-cell disease exhibit greater functional connectivity and centrality in the locus coeruleus compared to anemic controls
topic Regular Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6356008/
https://www.ncbi.nlm.nih.gov/pubmed/30690419
http://dx.doi.org/10.1016/j.nicl.2019.101686
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