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MyomiRNAs Dysregulation in ALS Rehabilitation

Amyotrophic lateral sclerosis (ALS) is a rare, progressive, neurodegenerative disorder caused by degeneration of upper and lower motor neurons. The disease process leads, because of lower motor neuron involvement, to progressive muscle atrophy, weakness, and fasciculations and for the upper motor ne...

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Autores principales: Pegoraro, Valentina, Merico, Antonio, Angelini, Corrado
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6356197/
https://www.ncbi.nlm.nih.gov/pubmed/30634563
http://dx.doi.org/10.3390/brainsci9010008
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author Pegoraro, Valentina
Merico, Antonio
Angelini, Corrado
author_facet Pegoraro, Valentina
Merico, Antonio
Angelini, Corrado
author_sort Pegoraro, Valentina
collection PubMed
description Amyotrophic lateral sclerosis (ALS) is a rare, progressive, neurodegenerative disorder caused by degeneration of upper and lower motor neurons. The disease process leads, because of lower motor neuron involvement, to progressive muscle atrophy, weakness, and fasciculations and for the upper motor neuron involvement leads to spasticity. Muscle atrophy in ALS is caused by a neural dysregulation in the molecular network controlling fast and slow muscle fibers. Denervation and reinnervation processes in skeletal muscle occur in the course of ALS and are modulated by rehabilitation. MicroRNAs (miRNAs) are small, non-coding RNAs that are involved in different biological functions under various pathophysiological conditions. MiRNAs can be secreted by various cell types and they are markedly stable in body fluids. MiR-1, miR-133 a miR-133b, and miR-206 are called “myomiRs” and are considered markers of myogenesis during muscle regeneration and contribute to neuromuscular junction stabilization or sprouting. We observed a positive effect of a standard aerobic exercise rehabilitative protocol conducted for six weeks in 18 ALS patients during hospitalization in our center. This is a preliminary study, in which we correlated clinical scales with molecular data on myomiRs. After six weeks of moderate aerobic exercise, we found lower levels in serum of myomiRNAs. Our data suggest that circulating miRNAs changed during skeletal muscle recovery in response to physical rehabilitation in ALS. However, no firm conclusions can be made on the ALS-specific effect of exercise on miRNA levels.
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spelling pubmed-63561972019-02-05 MyomiRNAs Dysregulation in ALS Rehabilitation Pegoraro, Valentina Merico, Antonio Angelini, Corrado Brain Sci Article Amyotrophic lateral sclerosis (ALS) is a rare, progressive, neurodegenerative disorder caused by degeneration of upper and lower motor neurons. The disease process leads, because of lower motor neuron involvement, to progressive muscle atrophy, weakness, and fasciculations and for the upper motor neuron involvement leads to spasticity. Muscle atrophy in ALS is caused by a neural dysregulation in the molecular network controlling fast and slow muscle fibers. Denervation and reinnervation processes in skeletal muscle occur in the course of ALS and are modulated by rehabilitation. MicroRNAs (miRNAs) are small, non-coding RNAs that are involved in different biological functions under various pathophysiological conditions. MiRNAs can be secreted by various cell types and they are markedly stable in body fluids. MiR-1, miR-133 a miR-133b, and miR-206 are called “myomiRs” and are considered markers of myogenesis during muscle regeneration and contribute to neuromuscular junction stabilization or sprouting. We observed a positive effect of a standard aerobic exercise rehabilitative protocol conducted for six weeks in 18 ALS patients during hospitalization in our center. This is a preliminary study, in which we correlated clinical scales with molecular data on myomiRs. After six weeks of moderate aerobic exercise, we found lower levels in serum of myomiRNAs. Our data suggest that circulating miRNAs changed during skeletal muscle recovery in response to physical rehabilitation in ALS. However, no firm conclusions can be made on the ALS-specific effect of exercise on miRNA levels. MDPI 2019-01-10 /pmc/articles/PMC6356197/ /pubmed/30634563 http://dx.doi.org/10.3390/brainsci9010008 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Pegoraro, Valentina
Merico, Antonio
Angelini, Corrado
MyomiRNAs Dysregulation in ALS Rehabilitation
title MyomiRNAs Dysregulation in ALS Rehabilitation
title_full MyomiRNAs Dysregulation in ALS Rehabilitation
title_fullStr MyomiRNAs Dysregulation in ALS Rehabilitation
title_full_unstemmed MyomiRNAs Dysregulation in ALS Rehabilitation
title_short MyomiRNAs Dysregulation in ALS Rehabilitation
title_sort myomirnas dysregulation in als rehabilitation
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6356197/
https://www.ncbi.nlm.nih.gov/pubmed/30634563
http://dx.doi.org/10.3390/brainsci9010008
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