RNA Editors, Cofactors, and mRNA Targets: An Overview of the C-to-U RNA Editing Machinery and Its Implication in Human Disease

One of the most prevalent epitranscriptomic modifications is RNA editing. In higher eukaryotes, RNA editing is catalyzed by one of two classes of deaminases: ADAR family enzymes that catalyze A-to-I (read as G) editing, and AID/APOBEC family enzymes that catalyze C-to-U. ADAR-catalyzed deamination h...

Descripción completa

Detalles Bibliográficos
Autores principales: Lerner, Taga, Papavasiliou, F. Nina, Pecori, Riccardo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6356216/
https://www.ncbi.nlm.nih.gov/pubmed/30591678
http://dx.doi.org/10.3390/genes10010013
_version_ 1783391480702828544
author Lerner, Taga
Papavasiliou, F. Nina
Pecori, Riccardo
author_facet Lerner, Taga
Papavasiliou, F. Nina
Pecori, Riccardo
author_sort Lerner, Taga
collection PubMed
description One of the most prevalent epitranscriptomic modifications is RNA editing. In higher eukaryotes, RNA editing is catalyzed by one of two classes of deaminases: ADAR family enzymes that catalyze A-to-I (read as G) editing, and AID/APOBEC family enzymes that catalyze C-to-U. ADAR-catalyzed deamination has been studied extensively. Here we focus on AID/APOBEC-catalyzed editing, and review the emergent knowledge regarding C-to-U editing consequences in the context of human disease.
format Online
Article
Text
id pubmed-6356216
institution National Center for Biotechnology Information
language English
publishDate 2018
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-63562162019-02-04 RNA Editors, Cofactors, and mRNA Targets: An Overview of the C-to-U RNA Editing Machinery and Its Implication in Human Disease Lerner, Taga Papavasiliou, F. Nina Pecori, Riccardo Genes (Basel) Review One of the most prevalent epitranscriptomic modifications is RNA editing. In higher eukaryotes, RNA editing is catalyzed by one of two classes of deaminases: ADAR family enzymes that catalyze A-to-I (read as G) editing, and AID/APOBEC family enzymes that catalyze C-to-U. ADAR-catalyzed deamination has been studied extensively. Here we focus on AID/APOBEC-catalyzed editing, and review the emergent knowledge regarding C-to-U editing consequences in the context of human disease. MDPI 2018-12-27 /pmc/articles/PMC6356216/ /pubmed/30591678 http://dx.doi.org/10.3390/genes10010013 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Lerner, Taga
Papavasiliou, F. Nina
Pecori, Riccardo
RNA Editors, Cofactors, and mRNA Targets: An Overview of the C-to-U RNA Editing Machinery and Its Implication in Human Disease
title RNA Editors, Cofactors, and mRNA Targets: An Overview of the C-to-U RNA Editing Machinery and Its Implication in Human Disease
title_full RNA Editors, Cofactors, and mRNA Targets: An Overview of the C-to-U RNA Editing Machinery and Its Implication in Human Disease
title_fullStr RNA Editors, Cofactors, and mRNA Targets: An Overview of the C-to-U RNA Editing Machinery and Its Implication in Human Disease
title_full_unstemmed RNA Editors, Cofactors, and mRNA Targets: An Overview of the C-to-U RNA Editing Machinery and Its Implication in Human Disease
title_short RNA Editors, Cofactors, and mRNA Targets: An Overview of the C-to-U RNA Editing Machinery and Its Implication in Human Disease
title_sort rna editors, cofactors, and mrna targets: an overview of the c-to-u rna editing machinery and its implication in human disease
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6356216/
https://www.ncbi.nlm.nih.gov/pubmed/30591678
http://dx.doi.org/10.3390/genes10010013
work_keys_str_mv AT lernertaga rnaeditorscofactorsandmrnatargetsanoverviewofthectournaeditingmachineryanditsimplicationinhumandisease
AT papavasilioufnina rnaeditorscofactorsandmrnatargetsanoverviewofthectournaeditingmachineryanditsimplicationinhumandisease
AT pecoririccardo rnaeditorscofactorsandmrnatargetsanoverviewofthectournaeditingmachineryanditsimplicationinhumandisease

Ejemplares similares