Obesity-Induced TNFα and IL-6 Signaling: The Missing Link between Obesity and Inflammation—Driven Liver and Colorectal Cancers

Obesity promotes the development of numerous cancers, such as liver and colorectal cancers, which is at least partly due to obesity-induced, chronic, low-grade inflammation. In particular, the recruitment and activation of immune cell subsets in the white adipose tissue systemically increase proinfl...

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Autores principales: Kern, Lara, Mittenbühler, Melanie J., Vesting, Anna Juliane, Ostermann, Anna Lena, Wunderlich, Claudia Maria, Wunderlich, F. Thomas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6356226/
https://www.ncbi.nlm.nih.gov/pubmed/30591653
http://dx.doi.org/10.3390/cancers11010024
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author Kern, Lara
Mittenbühler, Melanie J.
Vesting, Anna Juliane
Ostermann, Anna Lena
Wunderlich, Claudia Maria
Wunderlich, F. Thomas
author_facet Kern, Lara
Mittenbühler, Melanie J.
Vesting, Anna Juliane
Ostermann, Anna Lena
Wunderlich, Claudia Maria
Wunderlich, F. Thomas
author_sort Kern, Lara
collection PubMed
description Obesity promotes the development of numerous cancers, such as liver and colorectal cancers, which is at least partly due to obesity-induced, chronic, low-grade inflammation. In particular, the recruitment and activation of immune cell subsets in the white adipose tissue systemically increase proinflammatory cytokines, such as tumor necrosis factor α (TNFα) and interleukin-6 (IL-6). These proinflammatory cytokines not only impair insulin action in metabolic tissues, but also favor cancer development. Here, we review the current state of knowledge on how obesity affects inflammatory TNFα and IL-6 signaling in hepatocellular carcinoma and colorectal cancers.
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spelling pubmed-63562262019-02-05 Obesity-Induced TNFα and IL-6 Signaling: The Missing Link between Obesity and Inflammation—Driven Liver and Colorectal Cancers Kern, Lara Mittenbühler, Melanie J. Vesting, Anna Juliane Ostermann, Anna Lena Wunderlich, Claudia Maria Wunderlich, F. Thomas Cancers (Basel) Review Obesity promotes the development of numerous cancers, such as liver and colorectal cancers, which is at least partly due to obesity-induced, chronic, low-grade inflammation. In particular, the recruitment and activation of immune cell subsets in the white adipose tissue systemically increase proinflammatory cytokines, such as tumor necrosis factor α (TNFα) and interleukin-6 (IL-6). These proinflammatory cytokines not only impair insulin action in metabolic tissues, but also favor cancer development. Here, we review the current state of knowledge on how obesity affects inflammatory TNFα and IL-6 signaling in hepatocellular carcinoma and colorectal cancers. MDPI 2018-12-27 /pmc/articles/PMC6356226/ /pubmed/30591653 http://dx.doi.org/10.3390/cancers11010024 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Kern, Lara
Mittenbühler, Melanie J.
Vesting, Anna Juliane
Ostermann, Anna Lena
Wunderlich, Claudia Maria
Wunderlich, F. Thomas
Obesity-Induced TNFα and IL-6 Signaling: The Missing Link between Obesity and Inflammation—Driven Liver and Colorectal Cancers
title Obesity-Induced TNFα and IL-6 Signaling: The Missing Link between Obesity and Inflammation—Driven Liver and Colorectal Cancers
title_full Obesity-Induced TNFα and IL-6 Signaling: The Missing Link between Obesity and Inflammation—Driven Liver and Colorectal Cancers
title_fullStr Obesity-Induced TNFα and IL-6 Signaling: The Missing Link between Obesity and Inflammation—Driven Liver and Colorectal Cancers
title_full_unstemmed Obesity-Induced TNFα and IL-6 Signaling: The Missing Link between Obesity and Inflammation—Driven Liver and Colorectal Cancers
title_short Obesity-Induced TNFα and IL-6 Signaling: The Missing Link between Obesity and Inflammation—Driven Liver and Colorectal Cancers
title_sort obesity-induced tnfα and il-6 signaling: the missing link between obesity and inflammation—driven liver and colorectal cancers
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6356226/
https://www.ncbi.nlm.nih.gov/pubmed/30591653
http://dx.doi.org/10.3390/cancers11010024
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