Oxidative Insults and Mitochondrial DNA Mutation Promote Enhanced Autophagy and Mitophagy Compromising Cell Viability in Pluripotent Cell Model of Mitochondrial Disease

Dysfunction of mitochondria causes defects in oxidative phosphorylation system (OXPHOS) and increased production of reactive oxygen species (ROS) triggering the activation of the cell death pathway that underlies the pathogenesis of aging and various diseases. The process of autophagy to degrade dam...

Descripción completa

Detalles Bibliográficos
Autores principales: Lin, Dar-Shong, Huang, Yu-Wen, Ho, Che-Sheng, Hung, Pi-Lien, Hsu, Mei-Hsin, Wang, Tuan-Jen, Wu, Tsu-Yen, Lee, Tsung-Han, Huang, Zo-Darr, Chang, Po-Chun, Chiang, Ming-Fu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6356288/
https://www.ncbi.nlm.nih.gov/pubmed/30658448
http://dx.doi.org/10.3390/cells8010065

Ejemplares similares

Ejemplares similares