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The Effect of Vitamin D Supplementation on Hepcidin, Iron Status, and Inflammation in Pregnant Women in the United Kingdom

Iron and vitamin D deficiencies are common during pregnancy. Our aim was to identify whether antenatal vitamin D(3) supplementation affects iron status (via hepcidin suppression) and/or inflammation. Using a subset of the UK multicenter Maternal Vitamin D Osteoporosis Study (MAVIDOS)—a double-blinde...

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Autores principales: Braithwaite, Vickie S., Crozier, Sarah R., D’Angelo, Stefania, Prentice, Ann, Cooper, Cyrus, Harvey, Nicholas C., Jones, Kerry S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6356300/
https://www.ncbi.nlm.nih.gov/pubmed/30669280
http://dx.doi.org/10.3390/nu11010190
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author Braithwaite, Vickie S.
Crozier, Sarah R.
D’Angelo, Stefania
Prentice, Ann
Cooper, Cyrus
Harvey, Nicholas C.
Jones, Kerry S.
author_facet Braithwaite, Vickie S.
Crozier, Sarah R.
D’Angelo, Stefania
Prentice, Ann
Cooper, Cyrus
Harvey, Nicholas C.
Jones, Kerry S.
author_sort Braithwaite, Vickie S.
collection PubMed
description Iron and vitamin D deficiencies are common during pregnancy. Our aim was to identify whether antenatal vitamin D(3) supplementation affects iron status (via hepcidin suppression) and/or inflammation. Using a subset of the UK multicenter Maternal Vitamin D Osteoporosis Study (MAVIDOS)—a double-blinded, randomized, placebo-controlled trial (ISRCTN82927713; EudraCT2007-001716-23)—we performed a secondary laboratory analysis. Women with blood samples from early and late pregnancy (vitamin D(3) (1000 IU/day from ~14 weeks gestation n = 93; placebo n = 102) who gave birth in the springtime (March–May) were selected as we anticipated seeing the greatest treatment group difference in change in 25-hydroxyvitamin D (25OHD) concentration. Outcomes were hepcidin, ferritin, C-reactive protein, and α1-acid glycoprotein concentration in late pregnancy (25OHD concentration was measured previously). By late pregnancy, 25OHD concentration increased by 17 nmol/L in the vitamin D(3) group and decreased by 11 nmol/L in the placebo group; hepcidin, ferritin, and inflammatory markers decreased but no treatment group differences were seen. In late pregnancy, positive relationships between 25OHD and hepcidin and 25OHD and ferritin in the placebo group were observed but not in the treatment group (group × 25OHD interaction, p < 0.02). Vitamin D(3) supplementation had no effect on hepcidin, ferritin, or inflammatory status suggesting no adjunctive value of vitamin D(3) in reducing rates of antenatal iron deficiency.
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spelling pubmed-63563002019-02-01 The Effect of Vitamin D Supplementation on Hepcidin, Iron Status, and Inflammation in Pregnant Women in the United Kingdom Braithwaite, Vickie S. Crozier, Sarah R. D’Angelo, Stefania Prentice, Ann Cooper, Cyrus Harvey, Nicholas C. Jones, Kerry S. Nutrients Article Iron and vitamin D deficiencies are common during pregnancy. Our aim was to identify whether antenatal vitamin D(3) supplementation affects iron status (via hepcidin suppression) and/or inflammation. Using a subset of the UK multicenter Maternal Vitamin D Osteoporosis Study (MAVIDOS)—a double-blinded, randomized, placebo-controlled trial (ISRCTN82927713; EudraCT2007-001716-23)—we performed a secondary laboratory analysis. Women with blood samples from early and late pregnancy (vitamin D(3) (1000 IU/day from ~14 weeks gestation n = 93; placebo n = 102) who gave birth in the springtime (March–May) were selected as we anticipated seeing the greatest treatment group difference in change in 25-hydroxyvitamin D (25OHD) concentration. Outcomes were hepcidin, ferritin, C-reactive protein, and α1-acid glycoprotein concentration in late pregnancy (25OHD concentration was measured previously). By late pregnancy, 25OHD concentration increased by 17 nmol/L in the vitamin D(3) group and decreased by 11 nmol/L in the placebo group; hepcidin, ferritin, and inflammatory markers decreased but no treatment group differences were seen. In late pregnancy, positive relationships between 25OHD and hepcidin and 25OHD and ferritin in the placebo group were observed but not in the treatment group (group × 25OHD interaction, p < 0.02). Vitamin D(3) supplementation had no effect on hepcidin, ferritin, or inflammatory status suggesting no adjunctive value of vitamin D(3) in reducing rates of antenatal iron deficiency. MDPI 2019-01-18 /pmc/articles/PMC6356300/ /pubmed/30669280 http://dx.doi.org/10.3390/nu11010190 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Braithwaite, Vickie S.
Crozier, Sarah R.
D’Angelo, Stefania
Prentice, Ann
Cooper, Cyrus
Harvey, Nicholas C.
Jones, Kerry S.
The Effect of Vitamin D Supplementation on Hepcidin, Iron Status, and Inflammation in Pregnant Women in the United Kingdom
title The Effect of Vitamin D Supplementation on Hepcidin, Iron Status, and Inflammation in Pregnant Women in the United Kingdom
title_full The Effect of Vitamin D Supplementation on Hepcidin, Iron Status, and Inflammation in Pregnant Women in the United Kingdom
title_fullStr The Effect of Vitamin D Supplementation on Hepcidin, Iron Status, and Inflammation in Pregnant Women in the United Kingdom
title_full_unstemmed The Effect of Vitamin D Supplementation on Hepcidin, Iron Status, and Inflammation in Pregnant Women in the United Kingdom
title_short The Effect of Vitamin D Supplementation on Hepcidin, Iron Status, and Inflammation in Pregnant Women in the United Kingdom
title_sort effect of vitamin d supplementation on hepcidin, iron status, and inflammation in pregnant women in the united kingdom
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6356300/
https://www.ncbi.nlm.nih.gov/pubmed/30669280
http://dx.doi.org/10.3390/nu11010190
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