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Evaluation of γ-oryzanol Accumulation and Lipid Metabolism in the Body of Mice Following Long-Term Administration of γ-oryzanol

γ-Oryzanol (OZ), abundant in rice bran oil, has gained attention due to its physiological activities (e.g., lipid-lowering effects). However, the absorption and metabolism of orally ingested OZ have not yet been fully elucidated. In this study, diets containing normal or high contents of OZ were fed...

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Autores principales: Kobayashi, Eri, Ito, Junya, Shimizu, Naoki, Kokumai, Takumi, Kato, Shunji, Sawada, Kazue, Hashimoto, Hiroyuki, Eitsuka, Takahiro, Miyazawa, Teruo, Nakagawa, Kiyotaka
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6356301/
https://www.ncbi.nlm.nih.gov/pubmed/30621350
http://dx.doi.org/10.3390/nu11010104
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author Kobayashi, Eri
Ito, Junya
Shimizu, Naoki
Kokumai, Takumi
Kato, Shunji
Sawada, Kazue
Hashimoto, Hiroyuki
Eitsuka, Takahiro
Miyazawa, Teruo
Nakagawa, Kiyotaka
author_facet Kobayashi, Eri
Ito, Junya
Shimizu, Naoki
Kokumai, Takumi
Kato, Shunji
Sawada, Kazue
Hashimoto, Hiroyuki
Eitsuka, Takahiro
Miyazawa, Teruo
Nakagawa, Kiyotaka
author_sort Kobayashi, Eri
collection PubMed
description γ-Oryzanol (OZ), abundant in rice bran oil, has gained attention due to its physiological activities (e.g., lipid-lowering effects). However, the absorption and metabolism of orally ingested OZ have not yet been fully elucidated. In this study, diets containing normal or high contents of OZ were fed to obesity model mice for 8 weeks, and OZ concentrations in plasma and organs were analyzed by HPLC-MS/MS. To evaluate the relationship between OZ accumulation and lipid metabolism in vivo, lipid concentrations in the mice plasma and liver were also measured. As a result, the accumulation of intact OZ in plasma and organs was seen in mice fed diets containing OZ, where mice fed diets containing higher OZ contents demonstrated higher levels of OZ accumulation and lower amounts of plasma lipids. These results, in combination with our additional data from a single oral administration test, suggest the possibility that intact OZ, along with its metabolites (e.g., ferulic acid), is biologically-active.
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spelling pubmed-63563012019-02-01 Evaluation of γ-oryzanol Accumulation and Lipid Metabolism in the Body of Mice Following Long-Term Administration of γ-oryzanol Kobayashi, Eri Ito, Junya Shimizu, Naoki Kokumai, Takumi Kato, Shunji Sawada, Kazue Hashimoto, Hiroyuki Eitsuka, Takahiro Miyazawa, Teruo Nakagawa, Kiyotaka Nutrients Article γ-Oryzanol (OZ), abundant in rice bran oil, has gained attention due to its physiological activities (e.g., lipid-lowering effects). However, the absorption and metabolism of orally ingested OZ have not yet been fully elucidated. In this study, diets containing normal or high contents of OZ were fed to obesity model mice for 8 weeks, and OZ concentrations in plasma and organs were analyzed by HPLC-MS/MS. To evaluate the relationship between OZ accumulation and lipid metabolism in vivo, lipid concentrations in the mice plasma and liver were also measured. As a result, the accumulation of intact OZ in plasma and organs was seen in mice fed diets containing OZ, where mice fed diets containing higher OZ contents demonstrated higher levels of OZ accumulation and lower amounts of plasma lipids. These results, in combination with our additional data from a single oral administration test, suggest the possibility that intact OZ, along with its metabolites (e.g., ferulic acid), is biologically-active. MDPI 2019-01-06 /pmc/articles/PMC6356301/ /pubmed/30621350 http://dx.doi.org/10.3390/nu11010104 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Kobayashi, Eri
Ito, Junya
Shimizu, Naoki
Kokumai, Takumi
Kato, Shunji
Sawada, Kazue
Hashimoto, Hiroyuki
Eitsuka, Takahiro
Miyazawa, Teruo
Nakagawa, Kiyotaka
Evaluation of γ-oryzanol Accumulation and Lipid Metabolism in the Body of Mice Following Long-Term Administration of γ-oryzanol
title Evaluation of γ-oryzanol Accumulation and Lipid Metabolism in the Body of Mice Following Long-Term Administration of γ-oryzanol
title_full Evaluation of γ-oryzanol Accumulation and Lipid Metabolism in the Body of Mice Following Long-Term Administration of γ-oryzanol
title_fullStr Evaluation of γ-oryzanol Accumulation and Lipid Metabolism in the Body of Mice Following Long-Term Administration of γ-oryzanol
title_full_unstemmed Evaluation of γ-oryzanol Accumulation and Lipid Metabolism in the Body of Mice Following Long-Term Administration of γ-oryzanol
title_short Evaluation of γ-oryzanol Accumulation and Lipid Metabolism in the Body of Mice Following Long-Term Administration of γ-oryzanol
title_sort evaluation of γ-oryzanol accumulation and lipid metabolism in the body of mice following long-term administration of γ-oryzanol
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6356301/
https://www.ncbi.nlm.nih.gov/pubmed/30621350
http://dx.doi.org/10.3390/nu11010104
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