Cargando…

Women Remain at Risk of Iodine Deficiency during Pregnancy: The Importance of Iodine Supplementation before Conception and Throughout Gestation

In Australia, pregnant women are advised to take an iodine supplement (I-supp) (150 µg/day) to reduce risks to the foetus associated with iodine deficiency (ID). To examine the impact of this recommendation on iodine status, and to identify factors that contribute to adequacy during gestation, suppl...

Descripción completa

Detalles Bibliográficos
Autores principales: Hynes, Kristen L., Seal, Judy A., Otahal, Petr, Oddy, Wendy H., Burgess, John R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6356319/
https://www.ncbi.nlm.nih.gov/pubmed/30650544
http://dx.doi.org/10.3390/nu11010172
_version_ 1783391506860605440
author Hynes, Kristen L.
Seal, Judy A.
Otahal, Petr
Oddy, Wendy H.
Burgess, John R.
author_facet Hynes, Kristen L.
Seal, Judy A.
Otahal, Petr
Oddy, Wendy H.
Burgess, John R.
author_sort Hynes, Kristen L.
collection PubMed
description In Australia, pregnant women are advised to take an iodine supplement (I-supp) (150 µg/day) to reduce risks to the foetus associated with iodine deficiency (ID). To examine the impact of this recommendation on iodine status, and to identify factors that contribute to adequacy during gestation, supplement use and Urinary Iodine Concentration (UIC) was measured in 255 pregnant women (gestation range 6 to 41 weeks) in Tasmania. The median UIC (MUIC) of 133 µg/L (Inter-quartile range 82–233) was indicative of ID, being below the 150–249 µg/L range for adequacy during pregnancy. Women taking an iodine-containing-supplement (I-supp) had a significantly higher MUIC (155 µg/L) (n = 171) compared to the combined MUIC (112.5 µg/L) (n = 84) of those who had never (120 µg/L) (n = 61) or were no longer taking an I-supp (90 µg/L) (n = 23) (p = 0.017). Among women reporting I-supp use, the MUIC of those commencing the recommended 150 µg/day prior to conception was significantly higher than those starting supplementation following pregnancy confirmation: 196 (98–315) µg/L (n = 45) versus 137.5 (82.5–233.5) µg/L (n = 124), p = 0.032. Despite recommendations for iodine supplementation pregnant Tasmanian women remain at risk of ID. Commencing an I-supp of 150 µg/day prior to conception and continuing throughout pregnancy is required to ensure adequacy. Timely advice regarding the importance of adequate iodine nutrition, including supplementation is needed to reduce the risk of irreversible in utero neurocognitive damage to the foetus.
format Online
Article
Text
id pubmed-6356319
institution National Center for Biotechnology Information
language English
publishDate 2019
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-63563192019-02-01 Women Remain at Risk of Iodine Deficiency during Pregnancy: The Importance of Iodine Supplementation before Conception and Throughout Gestation Hynes, Kristen L. Seal, Judy A. Otahal, Petr Oddy, Wendy H. Burgess, John R. Nutrients Article In Australia, pregnant women are advised to take an iodine supplement (I-supp) (150 µg/day) to reduce risks to the foetus associated with iodine deficiency (ID). To examine the impact of this recommendation on iodine status, and to identify factors that contribute to adequacy during gestation, supplement use and Urinary Iodine Concentration (UIC) was measured in 255 pregnant women (gestation range 6 to 41 weeks) in Tasmania. The median UIC (MUIC) of 133 µg/L (Inter-quartile range 82–233) was indicative of ID, being below the 150–249 µg/L range for adequacy during pregnancy. Women taking an iodine-containing-supplement (I-supp) had a significantly higher MUIC (155 µg/L) (n = 171) compared to the combined MUIC (112.5 µg/L) (n = 84) of those who had never (120 µg/L) (n = 61) or were no longer taking an I-supp (90 µg/L) (n = 23) (p = 0.017). Among women reporting I-supp use, the MUIC of those commencing the recommended 150 µg/day prior to conception was significantly higher than those starting supplementation following pregnancy confirmation: 196 (98–315) µg/L (n = 45) versus 137.5 (82.5–233.5) µg/L (n = 124), p = 0.032. Despite recommendations for iodine supplementation pregnant Tasmanian women remain at risk of ID. Commencing an I-supp of 150 µg/day prior to conception and continuing throughout pregnancy is required to ensure adequacy. Timely advice regarding the importance of adequate iodine nutrition, including supplementation is needed to reduce the risk of irreversible in utero neurocognitive damage to the foetus. MDPI 2019-01-15 /pmc/articles/PMC6356319/ /pubmed/30650544 http://dx.doi.org/10.3390/nu11010172 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Hynes, Kristen L.
Seal, Judy A.
Otahal, Petr
Oddy, Wendy H.
Burgess, John R.
Women Remain at Risk of Iodine Deficiency during Pregnancy: The Importance of Iodine Supplementation before Conception and Throughout Gestation
title Women Remain at Risk of Iodine Deficiency during Pregnancy: The Importance of Iodine Supplementation before Conception and Throughout Gestation
title_full Women Remain at Risk of Iodine Deficiency during Pregnancy: The Importance of Iodine Supplementation before Conception and Throughout Gestation
title_fullStr Women Remain at Risk of Iodine Deficiency during Pregnancy: The Importance of Iodine Supplementation before Conception and Throughout Gestation
title_full_unstemmed Women Remain at Risk of Iodine Deficiency during Pregnancy: The Importance of Iodine Supplementation before Conception and Throughout Gestation
title_short Women Remain at Risk of Iodine Deficiency during Pregnancy: The Importance of Iodine Supplementation before Conception and Throughout Gestation
title_sort women remain at risk of iodine deficiency during pregnancy: the importance of iodine supplementation before conception and throughout gestation
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6356319/
https://www.ncbi.nlm.nih.gov/pubmed/30650544
http://dx.doi.org/10.3390/nu11010172
work_keys_str_mv AT hyneskristenl womenremainatriskofiodinedeficiencyduringpregnancytheimportanceofiodinesupplementationbeforeconceptionandthroughoutgestation
AT sealjudya womenremainatriskofiodinedeficiencyduringpregnancytheimportanceofiodinesupplementationbeforeconceptionandthroughoutgestation
AT otahalpetr womenremainatriskofiodinedeficiencyduringpregnancytheimportanceofiodinesupplementationbeforeconceptionandthroughoutgestation
AT oddywendyh womenremainatriskofiodinedeficiencyduringpregnancytheimportanceofiodinesupplementationbeforeconceptionandthroughoutgestation
AT burgessjohnr womenremainatriskofiodinedeficiencyduringpregnancytheimportanceofiodinesupplementationbeforeconceptionandthroughoutgestation