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Regression Analysis of Protoporphyrin IX Measurements Obtained during Dermatological Photodynamic Therapy

Photodynamic therapy (PDT) is a light activated drug therapy that can be used to treat a number of dermatological cancers and precancers. Improvement of efficacy is required to widen its application. Clinical protoporphyrin IX (PpIX) fluorescence data were obtained using a pre-validated, non-invasiv...

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Autores principales: Tyrrell, Jessica, Paterson, Cheryl, Curnow, Alison
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6356372/
https://www.ncbi.nlm.nih.gov/pubmed/30634715
http://dx.doi.org/10.3390/cancers11010072
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author Tyrrell, Jessica
Paterson, Cheryl
Curnow, Alison
author_facet Tyrrell, Jessica
Paterson, Cheryl
Curnow, Alison
author_sort Tyrrell, Jessica
collection PubMed
description Photodynamic therapy (PDT) is a light activated drug therapy that can be used to treat a number of dermatological cancers and precancers. Improvement of efficacy is required to widen its application. Clinical protoporphyrin IX (PpIX) fluorescence data were obtained using a pre-validated, non-invasive imaging system during routine methyl aminolevulinate (MAL)-PDT treatment of 172 patients with licensed dermatological indications (37.2% actinic keratosis, 27.3% superficial basal cell carcinoma and 35.5% Bowen’s disease). Linear and logistic regressions were employed to model any relationships between variables that may have affected PpIX accumulation and/or PpIX photobleaching during irradiation and thus clinical outcome at three months. Patient age was found to be associated with lower PpIX accumulation/photobleaching, however only a reduction in PpIX photobleaching appeared to consistently adversely affect treatment efficacy. Clinical clearance was reduced in lesions located on the limbs, hands and feet with lower PpIX accumulation and subsequent photobleaching adversely affecting the outcome achieved. If air cooling pain relief was employed during light irradiation, PpIX photobleaching was lower and this resulted in an approximate three-fold reduction in the likelihood of achieving clinical clearance. PpIX photobleaching during the first treatment was concluded to be an excellent predictor of clinical outcome across all lesion types.
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spelling pubmed-63563722019-02-05 Regression Analysis of Protoporphyrin IX Measurements Obtained during Dermatological Photodynamic Therapy Tyrrell, Jessica Paterson, Cheryl Curnow, Alison Cancers (Basel) Article Photodynamic therapy (PDT) is a light activated drug therapy that can be used to treat a number of dermatological cancers and precancers. Improvement of efficacy is required to widen its application. Clinical protoporphyrin IX (PpIX) fluorescence data were obtained using a pre-validated, non-invasive imaging system during routine methyl aminolevulinate (MAL)-PDT treatment of 172 patients with licensed dermatological indications (37.2% actinic keratosis, 27.3% superficial basal cell carcinoma and 35.5% Bowen’s disease). Linear and logistic regressions were employed to model any relationships between variables that may have affected PpIX accumulation and/or PpIX photobleaching during irradiation and thus clinical outcome at three months. Patient age was found to be associated with lower PpIX accumulation/photobleaching, however only a reduction in PpIX photobleaching appeared to consistently adversely affect treatment efficacy. Clinical clearance was reduced in lesions located on the limbs, hands and feet with lower PpIX accumulation and subsequent photobleaching adversely affecting the outcome achieved. If air cooling pain relief was employed during light irradiation, PpIX photobleaching was lower and this resulted in an approximate three-fold reduction in the likelihood of achieving clinical clearance. PpIX photobleaching during the first treatment was concluded to be an excellent predictor of clinical outcome across all lesion types. MDPI 2019-01-10 /pmc/articles/PMC6356372/ /pubmed/30634715 http://dx.doi.org/10.3390/cancers11010072 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Tyrrell, Jessica
Paterson, Cheryl
Curnow, Alison
Regression Analysis of Protoporphyrin IX Measurements Obtained during Dermatological Photodynamic Therapy
title Regression Analysis of Protoporphyrin IX Measurements Obtained during Dermatological Photodynamic Therapy
title_full Regression Analysis of Protoporphyrin IX Measurements Obtained during Dermatological Photodynamic Therapy
title_fullStr Regression Analysis of Protoporphyrin IX Measurements Obtained during Dermatological Photodynamic Therapy
title_full_unstemmed Regression Analysis of Protoporphyrin IX Measurements Obtained during Dermatological Photodynamic Therapy
title_short Regression Analysis of Protoporphyrin IX Measurements Obtained during Dermatological Photodynamic Therapy
title_sort regression analysis of protoporphyrin ix measurements obtained during dermatological photodynamic therapy
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6356372/
https://www.ncbi.nlm.nih.gov/pubmed/30634715
http://dx.doi.org/10.3390/cancers11010072
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