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Theoretical Modeling of Viscosity Monitoring with Vibrating Resonance Energy Transfer for Point-of-Care and Environmental Monitoring Applications
Förster resonance energy transfer (FRET) between two molecules in nanoscale distances is utilized in significant number of applications including biological and chemical applications, monitoring cellular activities, sensors, wireless communications and recently in nanoscale microfluidic radar design...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6356408/ https://www.ncbi.nlm.nih.gov/pubmed/30577634 http://dx.doi.org/10.3390/mi10010003 |
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author | Memisoglu, Gorkem Gulbahar, Burhan Zubia, Joseba Villatoro, Joel |
author_facet | Memisoglu, Gorkem Gulbahar, Burhan Zubia, Joseba Villatoro, Joel |
author_sort | Memisoglu, Gorkem |
collection | PubMed |
description | Förster resonance energy transfer (FRET) between two molecules in nanoscale distances is utilized in significant number of applications including biological and chemical applications, monitoring cellular activities, sensors, wireless communications and recently in nanoscale microfluidic radar design denoted by the vibrating FRET (VFRET) exploiting hybrid resonating graphene membrane and FRET design. In this article, a low hardware complexity and novel microfluidic viscosity monitoring system architecture is presented by exploiting VFRET in a novel microfluidic system design. The donor molecules in a microfluidic channel are acoustically vibrated resulting in VFRET in the case of nearby acceptor molecules detected with their periodic optical emission signals. VFRET does not require complicated hardware by directly utilizing molecular interactions detected with the conventional photodetectors. The proposed viscosity measurement system design is theoretically modeled and numerically simulated while the experimental challenges are discussed. It promises point-of-care and environmental monitoring applications including viscosity characterization of blood or polluted water. |
format | Online Article Text |
id | pubmed-6356408 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-63564082019-02-05 Theoretical Modeling of Viscosity Monitoring with Vibrating Resonance Energy Transfer for Point-of-Care and Environmental Monitoring Applications Memisoglu, Gorkem Gulbahar, Burhan Zubia, Joseba Villatoro, Joel Micromachines (Basel) Article Förster resonance energy transfer (FRET) between two molecules in nanoscale distances is utilized in significant number of applications including biological and chemical applications, monitoring cellular activities, sensors, wireless communications and recently in nanoscale microfluidic radar design denoted by the vibrating FRET (VFRET) exploiting hybrid resonating graphene membrane and FRET design. In this article, a low hardware complexity and novel microfluidic viscosity monitoring system architecture is presented by exploiting VFRET in a novel microfluidic system design. The donor molecules in a microfluidic channel are acoustically vibrated resulting in VFRET in the case of nearby acceptor molecules detected with their periodic optical emission signals. VFRET does not require complicated hardware by directly utilizing molecular interactions detected with the conventional photodetectors. The proposed viscosity measurement system design is theoretically modeled and numerically simulated while the experimental challenges are discussed. It promises point-of-care and environmental monitoring applications including viscosity characterization of blood or polluted water. MDPI 2018-12-21 /pmc/articles/PMC6356408/ /pubmed/30577634 http://dx.doi.org/10.3390/mi10010003 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Memisoglu, Gorkem Gulbahar, Burhan Zubia, Joseba Villatoro, Joel Theoretical Modeling of Viscosity Monitoring with Vibrating Resonance Energy Transfer for Point-of-Care and Environmental Monitoring Applications |
title | Theoretical Modeling of Viscosity Monitoring with Vibrating Resonance Energy Transfer for Point-of-Care and Environmental Monitoring Applications |
title_full | Theoretical Modeling of Viscosity Monitoring with Vibrating Resonance Energy Transfer for Point-of-Care and Environmental Monitoring Applications |
title_fullStr | Theoretical Modeling of Viscosity Monitoring with Vibrating Resonance Energy Transfer for Point-of-Care and Environmental Monitoring Applications |
title_full_unstemmed | Theoretical Modeling of Viscosity Monitoring with Vibrating Resonance Energy Transfer for Point-of-Care and Environmental Monitoring Applications |
title_short | Theoretical Modeling of Viscosity Monitoring with Vibrating Resonance Energy Transfer for Point-of-Care and Environmental Monitoring Applications |
title_sort | theoretical modeling of viscosity monitoring with vibrating resonance energy transfer for point-of-care and environmental monitoring applications |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6356408/ https://www.ncbi.nlm.nih.gov/pubmed/30577634 http://dx.doi.org/10.3390/mi10010003 |
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