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Temporal Progression of Fatty Acids in Preterm and Term Human Milk of Mothers from Switzerland

We longitudinally compared fatty acids (FA) from human milk (HM) of mothers delivering term and preterm infants. HM was collected for 4 months postpartum at 12 time points for preterm and for 2 months postpartum at 8 time points for term group. Samples were collected from the first feed of the morni...

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Autores principales: Thakkar, Sagar K., De Castro, Carlos Antonio, Beauport, Lydie, Tolsa, Jean-François, Fischer Fumeaux, Céline J., Affolter, Michael, Giuffrida, Francesca
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6356418/
https://www.ncbi.nlm.nih.gov/pubmed/30626044
http://dx.doi.org/10.3390/nu11010112
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author Thakkar, Sagar K.
De Castro, Carlos Antonio
Beauport, Lydie
Tolsa, Jean-François
Fischer Fumeaux, Céline J.
Affolter, Michael
Giuffrida, Francesca
author_facet Thakkar, Sagar K.
De Castro, Carlos Antonio
Beauport, Lydie
Tolsa, Jean-François
Fischer Fumeaux, Céline J.
Affolter, Michael
Giuffrida, Francesca
author_sort Thakkar, Sagar K.
collection PubMed
description We longitudinally compared fatty acids (FA) from human milk (HM) of mothers delivering term and preterm infants. HM was collected for 4 months postpartum at 12 time points for preterm and for 2 months postpartum at 8 time points for term group. Samples were collected from the first feed of the morning, and single breast was fully expressed. FA were analyzed by gas chromatography coupled with flame ionization detector. Oleic, palmitic and linoleic acids were the most abundant FA across lactation and in both groups. Preterm colostrum contained significantly (p < 0.05) higher 8:0, 10:0, 12:0, sum medium chain fatty acids (MCFA), 18:3 n-3 FA compared to term counterparts. Preterm mature milk contained significantly higher 12:0, 14:0, 18:2 n-6, sum saturated fatty acids (SFA), and sum MCFA. We did not observe any significant differences between the preterm and term groups for docosahexaenoic acid, arachidonic acid and eicosapentaenoic acid at any stage of lactation. Overall, preterm milk was higher for SFA with a major contribution from MCFA and higher in 18:2 n-6. These observational differences needs to be studied further for their implications on preterm developmental outcomes and on fortification strategies of either mothers’ own milk or donor human milk.
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spelling pubmed-63564182019-02-01 Temporal Progression of Fatty Acids in Preterm and Term Human Milk of Mothers from Switzerland Thakkar, Sagar K. De Castro, Carlos Antonio Beauport, Lydie Tolsa, Jean-François Fischer Fumeaux, Céline J. Affolter, Michael Giuffrida, Francesca Nutrients Article We longitudinally compared fatty acids (FA) from human milk (HM) of mothers delivering term and preterm infants. HM was collected for 4 months postpartum at 12 time points for preterm and for 2 months postpartum at 8 time points for term group. Samples were collected from the first feed of the morning, and single breast was fully expressed. FA were analyzed by gas chromatography coupled with flame ionization detector. Oleic, palmitic and linoleic acids were the most abundant FA across lactation and in both groups. Preterm colostrum contained significantly (p < 0.05) higher 8:0, 10:0, 12:0, sum medium chain fatty acids (MCFA), 18:3 n-3 FA compared to term counterparts. Preterm mature milk contained significantly higher 12:0, 14:0, 18:2 n-6, sum saturated fatty acids (SFA), and sum MCFA. We did not observe any significant differences between the preterm and term groups for docosahexaenoic acid, arachidonic acid and eicosapentaenoic acid at any stage of lactation. Overall, preterm milk was higher for SFA with a major contribution from MCFA and higher in 18:2 n-6. These observational differences needs to be studied further for their implications on preterm developmental outcomes and on fortification strategies of either mothers’ own milk or donor human milk. MDPI 2019-01-08 /pmc/articles/PMC6356418/ /pubmed/30626044 http://dx.doi.org/10.3390/nu11010112 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Thakkar, Sagar K.
De Castro, Carlos Antonio
Beauport, Lydie
Tolsa, Jean-François
Fischer Fumeaux, Céline J.
Affolter, Michael
Giuffrida, Francesca
Temporal Progression of Fatty Acids in Preterm and Term Human Milk of Mothers from Switzerland
title Temporal Progression of Fatty Acids in Preterm and Term Human Milk of Mothers from Switzerland
title_full Temporal Progression of Fatty Acids in Preterm and Term Human Milk of Mothers from Switzerland
title_fullStr Temporal Progression of Fatty Acids in Preterm and Term Human Milk of Mothers from Switzerland
title_full_unstemmed Temporal Progression of Fatty Acids in Preterm and Term Human Milk of Mothers from Switzerland
title_short Temporal Progression of Fatty Acids in Preterm and Term Human Milk of Mothers from Switzerland
title_sort temporal progression of fatty acids in preterm and term human milk of mothers from switzerland
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6356418/
https://www.ncbi.nlm.nih.gov/pubmed/30626044
http://dx.doi.org/10.3390/nu11010112
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