Perspective: Mitochondria-ER Contacts in Metabolic Cellular Stress Assessed by Microscopy

The interplay of mitochondria with the endoplasmic reticulum and their connections, called mitochondria-ER contacts (MERCs) or mitochondria-associated ER membranes (MAMs), are crucial hubs in cellular stress. These sites are essential for the passage of calcium ions, reactive oxygen species delivery...

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Detalles Bibliográficos
Autores principales: Stacchiotti, Alessandra, Favero, Gaia, Lavazza, Antonio, Garcia-Gomez, Raquel, Monsalve, Maria, Rezzani, Rita
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Perspective
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6356439/
https://www.ncbi.nlm.nih.gov/pubmed/30577576
http://dx.doi.org/10.3390/cells8010005
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author Stacchiotti, Alessandra
Favero, Gaia
Lavazza, Antonio
Garcia-Gomez, Raquel
Monsalve, Maria
Rezzani, Rita
author_facet Stacchiotti, Alessandra
Favero, Gaia
Lavazza, Antonio
Garcia-Gomez, Raquel
Monsalve, Maria
Rezzani, Rita
author_sort Stacchiotti, Alessandra
collection PubMed
description The interplay of mitochondria with the endoplasmic reticulum and their connections, called mitochondria-ER contacts (MERCs) or mitochondria-associated ER membranes (MAMs), are crucial hubs in cellular stress. These sites are essential for the passage of calcium ions, reactive oxygen species delivery, the sorting of lipids in whole-body metabolism. In this perspective article, we focus on microscopic evidences of the pivotal role of MERCs/MAMs and their changes in metabolic diseases, like obesity, diabetes, and neurodegeneration.
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spelling pubmed-63564392019-02-06 Perspective: Mitochondria-ER Contacts in Metabolic Cellular Stress Assessed by Microscopy Stacchiotti, Alessandra Favero, Gaia Lavazza, Antonio Garcia-Gomez, Raquel Monsalve, Maria Rezzani, Rita Cells Perspective The interplay of mitochondria with the endoplasmic reticulum and their connections, called mitochondria-ER contacts (MERCs) or mitochondria-associated ER membranes (MAMs), are crucial hubs in cellular stress. These sites are essential for the passage of calcium ions, reactive oxygen species delivery, the sorting of lipids in whole-body metabolism. In this perspective article, we focus on microscopic evidences of the pivotal role of MERCs/MAMs and their changes in metabolic diseases, like obesity, diabetes, and neurodegeneration. MDPI 2018-12-21 /pmc/articles/PMC6356439/ /pubmed/30577576 http://dx.doi.org/10.3390/cells8010005 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Perspective
Stacchiotti, Alessandra
Favero, Gaia
Lavazza, Antonio
Garcia-Gomez, Raquel
Monsalve, Maria
Rezzani, Rita
Perspective: Mitochondria-ER Contacts in Metabolic Cellular Stress Assessed by Microscopy
title Perspective: Mitochondria-ER Contacts in Metabolic Cellular Stress Assessed by Microscopy
title_full Perspective: Mitochondria-ER Contacts in Metabolic Cellular Stress Assessed by Microscopy
title_fullStr Perspective: Mitochondria-ER Contacts in Metabolic Cellular Stress Assessed by Microscopy
title_full_unstemmed Perspective: Mitochondria-ER Contacts in Metabolic Cellular Stress Assessed by Microscopy
title_short Perspective: Mitochondria-ER Contacts in Metabolic Cellular Stress Assessed by Microscopy
title_sort perspective: mitochondria-er contacts in metabolic cellular stress assessed by microscopy
topic Perspective
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6356439/
https://www.ncbi.nlm.nih.gov/pubmed/30577576
http://dx.doi.org/10.3390/cells8010005
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