Cargando…

Effect of Trehalose Supplementation on Autophagy and Cystogenesis in a Mouse Model of Polycystic Kidney Disease

Autophagy impairment has been demonstrated in the pathogenesis of autosomal dominant polycystic kidney disease (ADPKD) and could be a new target of treatment. Trehalose is a natural, nonreducing disaccharide that has been shown to enhance autophagy. Therefore, we investigated whether trehalose treat...

Descripción completa

Detalles Bibliográficos
Autores principales:	Chou, Li-Fang, Cheng, Ya-Lien, Hsieh, Chun-Yih, Lin, Chan-Yu, Yang, Huang-Yu, Chen, Yung-Chang, Hung, Cheng-Chieh, Tian, Ya-Chung, Yang, Chih-Wei, Chang, Ming-Yang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6356442/ https://www.ncbi.nlm.nih.gov/pubmed/30585217 http://dx.doi.org/10.3390/nu11010042

Ejemplares similares

Is autophagy the culprit of cystogenesis in polycystic kidney disease?
por: Wang, Shixuan, et al.
Publicado: (2020)

Autosomal Dominant Polycystic Kidney Disease: From Pathophysiology of Cystogenesis to Advances in the Treatment
por: Reiterová, Jana, et al.
Publicado: (2022)

Autophagy-mediated reduction of miR-345 contributes to hepatic cystogenesis in polycystic liver disease
por: Masyuk, Tatyana, et al.
Publicado: (2021)

Organoid cystogenesis reveals a critical role of microenvironment in human polycystic kidney disease
por: Cruz, Nelly M., et al.
Publicado: (2017)

Effects of Suramin on Polycystic Kidney Disease in a Mouse Model of Polycystin-1 Deficiency
por: Chang, Ming-Yang, et al.
Publicado: (2022)

Ciliary exclusion of Polycystin-2 promotes kidney cystogenesis in an autosomal dominant polycystic kidney disease model
por: Walker, Rebecca V., et al.
Publicado: (2019)

Renal expression of JAK2 is high in polycystic kidney disease and its inhibition reduces cystogenesis
por: Patera, Foteini, et al.
Publicado: (2019)

TAZ/Wnt-β-catenin/c-MYC axis regulates cystogenesis in polycystic kidney disease
por: Lee, Eun Ji, et al.
Publicado: (2020)

Novel zebrafish polycystic kidney disease models reveal functions of the Hippo pathway in renal cystogenesis
por: Ren, Zhiqin, et al.
Publicado: (2021)

Glucose absorption drives cystogenesis in a human organoid-on-chip model of polycystic kidney disease
por: Li, Sienna R., et al.
Publicado: (2022)

Everolimus halts hepatic cystogenesis in a rodent model of polycystic-liver-disease
por: Temmerman, Frederik, et al.
Publicado: (2017)

Mechanism of cystogenesis in nephrotic kidneys: a histopathological study
por: Saraga, Marijan, et al.
Publicado: (2014)

TFEB and TFE3 drive kidney cystogenesis and tumorigenesis
por: Di Malta, Chiara, et al.
Publicado: (2023)

Impaired epithelial Na(+) channels activity contributes to cystogenesis and development of autosomal recessive polycystic kidney disease in PCK rats
por: Pavlov, Tengis S., et al.
Publicado: (2014)

Synthetic Conjugates of Ursodeoxycholic Acid Inhibit Cystogenesis in Experimental Models of Polycystic Liver Disease
por: Caballero‐Camino, Francisco J., et al.
Publicado: (2020)

Ex Vivo Modeling of Chemical Synergy in Prenatal Kidney Cystogenesis
por: Anders, Corina, et al.
Publicado: (2013)

cAMP‐Induced Nuclear Condensation of CRTC2 Promotes Transcription Elongation and Cystogenesis in Autosomal Dominant Polycystic Kidney Disease
por: Mi, Zeyun, et al.
Publicado: (2022)

Kidney intercalated cells and the transcription factor FOXi1 drive cystogenesis in tuberous sclerosis complex
por: Barone, Sharon, et al.
Publicado: (2021)

Leptospirosis kidney disease: Evolution from acute to chronic kidney disease
por: Chou, Li-Fang, et al.
Publicado: (2023)

TRPV4 functional status in cystic cells regulates cystogenesis in autosomal recessive polycystic kidney disease during variations in dietary potassium
por: Pyrshev, Kyrylo, et al.
Publicado: (2023)

Ciliary ARL13B inhibits developmental kidney cystogenesis in mouse
por: Van Sciver, Robert E., et al.
Publicado: (2023)

Accelerated cystogenesis by dietary protein load is dependent on, but not initiated by kidney macrophages
por: Sedaka, Randee, et al.
Publicado: (2023)

Centrosome amplification disrupts renal development and causes cystogenesis
por: Dionne, Lai Kuan, et al.
Publicado: (2018)

Hepatocyte nuclear factor-1β: A regulator of kidney development and cystogenesis
por: Singh, V., et al.
Publicado: (2015)

Acute Kidney Injury Enhances Outcome Prediction Ability of Sequential Organ Failure Assessment Score in Critically Ill Patients
por: Chang, Chih-Hsiang, et al.
Publicado: (2014)

Supplemented Low-Protein Diet May Delay the Need for Preemptive Kidney Transplantation: A Nationwide Population-Based Cohort Study
por: Yen, Chieh-Li, et al.
Publicado: (2021)

Inhibition of NAE‐dependent protein hyper‐NEDDylation in cystic cholangiocytes halts cystogenesis in experimental models of polycystic liver disease
por: Lee‐Law, Pui Y., et al.
Publicado: (2021)

Serum Interleukin-18 at Commencement of Renal Replacement Therapy Predicts Short-Term Prognosis in Critically Ill Patients with Acute Kidney Injury
por: Lin, Chan-Yu, et al.
Publicado: (2013)

Impairment of Wnt11 function leads to kidney tubular abnormalities and secondary glomerular cystogenesis
por: Nagy, Irina I., et al.
Publicado: (2016)

Combination of curcumin and ginkgolide B inhibits cystogenesis by regulating multiple signaling pathways
por: Li, Yousong, et al.
Publicado: (2021)

cAMP‐Induced Nuclear Condensation of CRTC2 Promotes Transcription Elongation and Cystogenesis in Autosomal Dominant Polycystic Kidney Disease (Adv. Sci. 10/2022)
por: Mi, Zeyun, et al.
Publicado: (2022)

Hepatointestinal complications in polycystic kidney disease
por: Huang, Shih-Ting, et al.
Publicado: (2017)

The role of the exocyst in renal ciliogenesis, cystogenesis, tubulogenesis, and development
por: Lipschutz, Joshua H.
Publicado: (2019)

Cilia-Localized Counterregulatory Signals as Drivers of Renal Cystogenesis
por: Walker, Rebecca V., et al.
Publicado: (2022)

Risk Models and Scoring Systems for Predicting the Prognosis in Critically Ill Cirrhotic Patients with Acute Kidney Injury: A Prospective Validation Study
por: Pan, Heng-Chih, et al.
Publicado: (2012)

Young-Adult Polycystic Kidney Disease is Associated with Major Cardiovascular Complications
por: Chuang, Ya-Wen, et al.
Publicado: (2018)

Activation of TFEB-mediated autophagy by trehalose attenuates mitochondrial dysfunction in cisplatin-induced acute kidney injury
por: Zhu, Lingling, et al.
Publicado: (2020)

Clinical burden of autosomal dominant polycystic kidney disease
por: Hung, Peir-Haur, et al.
Publicado: (2020)

Acute Kidney Injury Biomarkers for Patients in a Coronary Care Unit: A Prospective Cohort Study
por: Chen, Tien-Hsing, et al.
Publicado: (2012)

Integrated Metabolomic and Transcriptomic Analysis of Acute Kidney Injury Caused by Leptospira Infection
por: Chen, Kuan-Hsing, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_47t195ivgir3v0qq7i92egpli6