Transfection with GLS2 Glutaminase (GAB) Sensitizes Human Glioblastoma Cell Lines to Oxidative Stress by a Common Mechanism Involving Suppression of the PI3K/AKT Pathway

GLS-encoded glutaminase promotes tumorigenesis, while GLS2-encoded glutaminase displays tumor-suppressive properties. In glioblastoma (GBM), the most aggressive brain tumor, GLS is highly expressed and in most cases GLS2 is silenced. Previously, it was shown that transfection with a sequence encodin...

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Detalles Bibliográficos
Autores principales: Majewska, Ewelina, Márquez, Javier, Albrecht, Jan, Szeliga, Monika
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6356507/
https://www.ncbi.nlm.nih.gov/pubmed/30669455
http://dx.doi.org/10.3390/cancers11010115

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6356507/
https://www.ncbi.nlm.nih.gov/pubmed/30669455
http://dx.doi.org/10.3390/cancers11010115

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